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Developmental Biology -Spring, 2012 13:30-15:20, every Wednesday Rm. N401, IMB

Developmental Biology -Spring, 2012 13:30-15:20, every Wednesday Rm. N401, IMB Organizer: Cheng-Ting Chien, E-mail: ctchien@gate.sinica.edu.tw ; TEL: 2789-9970.

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Developmental Biology -Spring, 2012 13:30-15:20, every Wednesday Rm. N401, IMB

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  1. Developmental Biology -Spring, 2012 13:30-15:20, every Wednesday Rm. N401, IMB Organizer: Cheng-Ting Chien, E-mail: ctchien@gate.sinica.edu.tw ; TEL: 2789-9970

  2. Textbooks: 1. Developmental Biology (8th ed.) by Scott F. Gilbert 2. Principles of Development (3rd ed.) by Lewis Wolpert

  3. Grading:1. homework, or 2. mid-term and final exams in open-book style.

  4. Cell Proliferation and death Lecturer: Dr. Guang-Chao Chen • Regulation of cell cycle • Cell signaling networks that control cell proliferation • Cell death in development • Regulation of cell death • Caspases and apoptosis • Bcl2 family members and the mitochondria in apoptosis • Autophagy and cell death

  5. Logic of regulatory circuits Lecturer: Dr. Y. Henry Sun Formation of organs • Cells • Tissues • Organs • Systems • Organisms • Society Questions • •Fate specification • •Cell differentiation • •Spatial and temporal coordination • •Growth control • •Coordination with other parts of body

  6. Cell fate specification Lecturer: Dr. Cheng-Ting Chien Gene expression and Development Progressive cell fate determination Neurogenin and NeuroD in vertebrate neural development Combinations of transcription factors determine different cell fates Requirement of MRFs at different stages Effect of knockout of myogenic genes in mice MRFs (muscle regulatory factor) and MEF (muscle enhancer-binding factor) Sites of E-box and MEF-box on muscle differentiation-specific genes Combinatorial codes to specify distinct cell fates along D/V axis Lhx3, an effector gene for V2 differentiation is not repressed in the p2 domain Common signaling pathways in development Three habits to signal effectively and specifically

  7. Embryonic development I Lecturer: Dr. Der-Hwa Huang 1. Brief introduction of fly life and key events in early embryo 2. Zygotic genes that affect segmentation and segmental identity 3. Events that depend on maternal products 4. Things begin during Oocyte formation— A/P polarity during oocyte formation. 5. Pre-patterning of A/P and D/V axis in oocyte.

  8. Embryonic development II Lecturer: Dr. Yu-Ting Yan Vascular heterotaxia in Cryptic–/–mice Randomized embryo turning and cardiac looping Absence of L-R asymmetric gene expression in the lateral plate mesoderm Absence of Nodal expression in the lateral plate, but not round the node Schematic model for EGF-CFCfunction in left-right axis formation An assay for EGF-CFC and Nodal activities Direct and indirect mechanisms for L-R defects Pathway for L-R axis specification The EGF-CFC gene family Cripto is required for A-P axis positioning Conserved elements of the L-R pathway The Nodal signaling pathway Gene expression and targeted disruption of Cryptic Randomized abdominal situs in Cryptic–/– mice Cardiac defects in Cryptic–/– mice

  9. Cell polarity and migration Lecturer: Dr. Ruey-Hwa Chen Basic principle to generate polarity Asymmetric distribution of PAR complex and other polarity complexes From polarity signal to polarity establishment Cell polarization in development Asymmetric cell division controls fly neurogenesis PAR and Scrib complexes facilitate the partition of apical and basal membrane

  10. A-P axis specification in C. elegans • Setting up polarity by PAR proteins • Cell migration- basic mechanism • Acitn nucleation & branch formation • Adhesion formation • Cell migration in Dictyostelium development • Chemotaxis • Polarized distribution of signaling proteins • Chemotactic signaling at front & back • Drosophila Border cell migration • Three pathways control border cell migration • Distal tip cell migration in C. elegans • Genes involved in DTC migration

  11. Neuronal development Lecturer: Dr. Yi-Ping Hsueh 1. Cell proliferation 2. Cell migration 3. Axon guidance and outgrowth a. Netrin/DCC b. Eph/ephrin 4. Dendrite outgrowth and field size. 5. Synaptic formation 6. Elimination of cells and synapses 7. Activity-dependent synaptic rearrangement

  12. Organogenesis on vertebrate systems Lecturer: Dr. Yun-Jin Jiang(NHRI) 1. Comparison of model organisms 2. Introduction to zebrafish development 3. Zebrafish kidney (pronephros) as an example 4. General introduction of pronephros function and development 5. Four major stage of pronephros development 6. Genes and signaling pathways involved in pronephros development 7. Role of Notch signaling in cell specification between multiciliated cells and principal (transporting epithelial) cells 8. Somite segmentaion as another example: temporal gene regulation leading to spatial boundary formation 9. Discovery of the segmentation clock 10. Somite mutant studies 11. Genes and pathways involved in somite formation 12. Their regulation and model

  13. Control and regulation of stem cells Lecturer: Dr. Hwei-Jan Hsu(ICOB) Embryonic stem cells, adult stem cells and cancer stem cells Hematopoietic stem cells Neural stem cells Germline stem cells Stem cell niches Niche signals, systemic signals and environmental factors that regulate stem cell function.

  14. Sex determination & differentiation Lecturer: Dr. Bon-chu Chung(IMB) • Sex determination by X chromosome numbers • Antagonism between Male and Female pathways • SRY determines testis formation • Sex in C. elegans and flies • Germ cell/somatic cell interaction • Steps in gonad differentiation

  15. Development of the immune system Lecturer: Dr. Kuo-I Lin (GRC) All the cellular components of the immune systemderive from a pluripotent hematopoietic stem cell Lymphocyte development B cell development The development of T cells DC development Myeloid development

  16. Senescence and ageing Lecturer: Dr. Ting-Fen Tsai(YMU) Aging Longevity Cellular senescence Age dependency Lifespan Healthspan Health

  17. Plant Development Lecturer: Dr. Shu-Hsing Wu(IPMB) Why plants? What are the current status of developmental biology in plants? • Embryogenesis • Vegetable growth: meristems and leaf development • Flowering time control • Reproductive growth: flower development

  18. Evo-Devo Lecturer: Dr. Jr-Kai Yu (ICOB) 1. A brief history of animals and evolutionary biology 2. Animal phylogeny 3. The genetic toolkit for development 4. Mechanisms of evolutionary change

  19. Development and Diseases Lecturer: Dr. June-Tai Wu(NTU) The lecture will mainly cover three topics: diseases related to anatomical defects introducing birth defects that reflect abnormalities in patterning during intrauterine development diseases related to functional defects introducing genetic diseases resulted from defects in terminal differentiation of a tissue psychiatric disease related to development introducing the developmental basis of psychiatric diseases, such as autism and schizophrenia.

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