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Ergotamine

Ergotamine. Ergometrine. Strychnine and Brucine: Nux-vomica Botanical source: Seed of S trychnus nux-vomica Loganiaceae. Very toxic compound which block Neurotransmission from the spinal cord to the brain. Used only for study the sympathetic and parasympathetic action of drug.

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Ergotamine

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  1. Ergotamine Ergometrine

  2. Strychnine and Brucine: • Nux-vomica • Botanical source: • Seed of Strychnus nux-vomica Loganiaceae. • Very toxic compound which block Neurotransmission from the spinal cord to the brain. • Used only for study the sympathetic and parasympathetic action of drug. • Detection : • Nitric acid: strychnine will give yellow PPT. • Brucine will give red PPT. • Chemical microscope:

  3. R= H: Strychnine R= OCH3: Brucine

  4. : Physostigmine and Neostigmine Alkaloid : • Biosynthetic origin: • Botanical source Botanical sours are seed of Physostigma vensum Fabaceae. • Common name (Calaber been). • :Pharmacological effect: • Irreversible chorine esterase inhibitor (parasympathomimmtic). • Used in acute open angle glaucoma will increase the contraction of ciliary's • muscle and increase excretion of aqueous hummer and will decrease IOP. • Give I.V or I.M for it toxicity, has unstable compound (ester and amide).

  5. Neostgmine: not indol alkaloid. • action normalize contraction of striated muscle by facilities nerve imbuls. • Has positive charge (4° alkaloid). • Soluble in water so can use be given S.C. • Used: • For diagnosis of myasthenia gravis. • Post operation Bladder surgery. • Side effect: Miosis, Convolution, Respiratory arrest, Brady cardiac.

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