1 / 11

Magda Carneiro-Sampaio, MD, PhD Hospital das Clínicas da Faculdade de Medicina

Magda Carneiro-Sampaio, MD, PhD Hospital das Clínicas da Faculdade de Medicina Universidade de São Paulo (FMUSP), Brazil. Primary Immunodeficiencies in 910 Brazilian patients of different age groups. > 30 years old: 227. 910 consecutive patients with well-defined PIDs*

camila
Download Presentation

Magda Carneiro-Sampaio, MD, PhD Hospital das Clínicas da Faculdade de Medicina

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Magda Carneiro-Sampaio, MD, PhD Hospital das Clínicas da Faculdade de Medicina Universidade de São Paulo (FMUSP), Brazil Primary Immunodeficiencies in 910 Brazilian patients of different age groups

  2. > 30 years old: 227 910 consecutive patients with well-defined PIDs* followed-up at Hospital das Clínicas da FMUSP and grouped according to age at diagnosis: • < 2 years old: 118 patients • 2 - 5 years old: 141 60 different PIDs were identified • 5 - 10 years old: 169 • 10 - 20 years old: 137 • 20 - 30 years old: 118 *Notarangelo et al. IUIS Experts Committee PID Classification JACI ; 124:1161, 2009

  3. Ethnicity of Brazilian people results from a mixture of native Indian, Portuguese and African descents, who have been merging since XVIth century

  4. In the last 120 years Brazil received significant Italian, Syrian-Lebanese and Japanese immigration Fotos de Priscila Oliveira, 2010

  5. Predominantly Antibody Deficiencies Combined T + B deficiencies Phagocyte number and/or function def Other Well defined PID syndromes Complement deficiencies Immune dysregulation diseases Innate immunity defects Autoinflammatory disorders Primary Immunodeficiencies (PID): Hospital das Clínicas da FMUSP’s Series (N=910) Magda Carneiro-Sampaio, Jorge E. Kalil, Alberto Duarte & cols, Primary Immunodeficiency Diseases in Brazilian Patients of Different Age Groups, 2010

  6. Distribution of HC-FMUSP PID patients (N = 910) according to age groups and the main IUIS PID categories

  7. 18% (XLA, THI) 5% 14% (HLH, IPEX) Distribution of the <2 years old patients (N=118) according to the main IUIS PID categories 14% (DiGeorge Syndrome) 2,5% 21% (CGD) 25% (SCID) 2,5%

  8. 1% 8% Distribution of the 2-5 years old patients (N=141) according to the main IUIS PID categories 16% 8% 14% 3,5% 48% (XLA, THI, IgAD) 1,5%

  9. Gender distribution in different age groups of HC-FMUSP PID series (N = 910) Age (years)

  10. Highly significant findings in the comparison between <5 years old X >5 years old PID groups Hospital das Clínicas FMUSP

  11. Faculdade de Medicina da Universidade de São Paulo Clinical staff in charge of PID patients follow-up at Hospital das Clínicas da FMUSP • Dept of Pediatrics (patients < 20 years-old): Magda Carneiro-Sampaio, Cristina Miuki A Jacob, Antonio Pastorino, Angela Bueno F Fomin, Mayra Dorna, Leticia Watanabe • Dept of Internal Medicine (patients >20 years-old): Jorge Kalil, Cristina Kokron, Myrthes Toledo Barros, Luiz Vicente Rizzo • Dept of Dermatology (patients with skin manifestations of all ages): Alberto Duarte, Dewton Moraes-Vasconcelos, Anete Sevciovic Grumach

More Related