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Learn about UTIs affecting urethra, bladder, ureters, and kidneys. Discover common pathogens, symptoms, risk factors, diagnosis, antibiotics, prevention strategies, and special considerations. Explore details on pyelonephritis infection and its management.
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Urinary Tract Infections Tory Davis, PA-C UNE PA Program
UTI • Can involve any part of urinary tract • Urethra • Bladder • Ureter(s) • Kidney(s) • Bladder and urethra most commonly involved
How, who and why • MC pathogen E.coli from GI tract (70-80%) • Also Enterococcus faecalis • In women: • Close proximity of urethra to anus • Short distance from urethral opening to bladder • In men: • more often due to obstruction, incl • Structural abnormalities • Catheterization • Neurogenic bladder • Enlarged prostate
Symptoms Can Indicate Location • Urethritis causes dysuria • Cystitis causes: • Urinary urgency & frequency, hematuria, suprapubic pain, malodorous urine • Pyelonephritis: • flank pain, fevers/chills, nausea/vomiting
Risk Factors • Female • Sexually active • Use of contraceptive diaphragm and/or spermicidal agents • Aging • Post meno estrogen causes thinner tissue in vag, urethra, bladder base
More risk factors • For both males and females: • Urinary tract obstruction • Immunocompromise • Urinary catheter -
Work up • History – past UTI, blood present, flank pain, recent intercourse (new bacteria), • PE • + CVAT (costoverterbral angle tenderness – bang on kidneys) – make you think pyelo.
Diagnosis • Clean-catch (midstream urine) • Dip for nitrites (b/c bac-t produce enzyme that converts urine nitrates to nitrites) and leukoesterases (protein produced by WBCs) • Microscopy for WBCs • Urine culture and sensitivity
Antibiotics • In an uncomplicated outpt, no catheter • Bactrim (TMP/SMX) DS (double strength) bid for 3 days • Fluoroquinolone (ie Ciprofloxacin) BID x 3 d • Amoxicillin+clavanulate (Augmentin) • Nitrofurantoin (Macrobid)
And have a heart.. • Urinary analgesic phenazopyridine (Pyridium) 200 mg TID prn dysuria • NB - Makes urine orange or blue
Tx other • Fluids- lots of water • Avoid bladder irritants- coffee, soda, alcohol • Cranberry- decreases ability of bac-t to adhere to bladder wall
UTI Prevention • Cranberry • Wipe front-to-back • Urinate after intercourse • Avoid irritants, incl feminine hygiene products and smoking • Shower rather than bath • Prophylactic abx for recurrent UTIs • Dosing: daily low dose vs post-sex dose vs prn symptomatic dosing
Special populations require special considerations • Like who? • What’s special about them?
Pyelonephritis • Ascending infection from lower urinary tract travels up ureters to the pyelum (pelvis) of the kidney (nephros) and causes an “–itis” • Or hematogenous spread • Not good • Sick people
Pyelo • Fevers • Rigors • Flank pain • Nausea/vomiting • + CVAT • +/- lower UTI sx • + blood cultures • But good hx and PE, plus urine may be enough
Pyelo Tx • Admission if fevers and leukocytosis • IV fluids • IV abx (Cipro, ampicillin if preg) • Continue abx until fever-free x 24h, but can switch to oral dosing when pt improves