Lecture 19

1. Lecture 19 Coordination and Control in Animals - 1

2. Systems of Coordination • Irritability is a characteristic of living organisms. • Ability to respond to a stimulus. • The stimulus is received by a receptor. • It is transmitted by nerves or hormones, and an effector brings about the response. • Animals have two systems of coordination, the nervous system and the endocrine system. • The nervous system coordinates rapid responses to external stimuli. The endocrine system controls slower, longer lasting responses to internal stimuli. • Activity of both systems is integrated.

3. The Nervous System • Three basic functions are performed by the nervous systems: • Receive sensory input from internal and external environments • Integrate the input • Respond to stimuli

4. Functions of Nervous System • Sensory input can be in many forms, including pressure, taste, sound, light, blood pH, or hormone levels, that are converted to a signal and sent to the brain or spinal cord. • In the sensory centres of the brain or in the spinal cord, the barrage of input is integrated and a response is generated. • The response, a motor output, is a signal transmitted to organs than can convert the signal into some form of action, such as movement, changes in heart rate, release of hormones

5. Divisions of the Nervous System • The nervous system monitors and controls almost every organ system through a series of positive and negative feedback loops. • The Central Nervous System (CNS) includes the brain and spinal cord. • The Peripheral Nervous System (PNS) connects the CNS to other parts of the body, and is composed of nerves (bundles of neurons).

6. Neuron • The cell has a nucleus contained in the cell body. • Dendrites carry impulses toward the cell body. • Axon transmits nerve impulse away from the cell body. • The axon breaks up into many some branches with swollen endings called synaptic knobs.

7. Nervous Tissue Forms a Communication Network

8. Neurons • Three types of neurons occur. • Sensory neurons typically have a long dendrite and short axon, and carry messages from sensory receptors to the central nervous system. • Motor neurons have a long axon and short dendrites and transmit messages from the central nervous system to the muscles (or to glands). • Interneurons are found only in the central nervous system where they connect neuron to neuron.

9. Three Types of Neurons Stimulus Sensory neuron Response Motor neuron Interneuron Effector Receptor synapse Muscle or gland

10. The Nerve Message • The plasma membrane of neurons, has an unequal distribution of ions and electrical charges between the two sides of the membrane. • The outside of the membrane has a (+), inside has is (-). • This charge difference is a resting potential and is measured in millivolts. • Passage of ions across the cell membrane passes the electrical charge along the cell. The voltage potential is -65mV (millivolts) of a cell at rest (resting potential). • Resting potential results from differences between sodium and potassium positively charged ions and negatively charged ions in the cytoplasm.

11. Nerve Impulse • 1/3 of energy used during rest is spent maintaining resting potential across all cells in your body! • Sodium ion [Na +] is constantly pumped to outside of cell. Meanwhile, potassium ion [K +] is pumped inside. • Sodium ions are more concentrated outside the membrane, while potassium ions are more concentrated inside the membrane. • Result: excess + charge outside membrane, excess – inside, called polarization. • When cell is stimulated to fire electrical signal => Action Potential

12. Action Potential An action potential is a temporary reversal of the electrical. potential along the membrane for a few milliseconds. • Stimulus (pressure, chemical, electrical) alters shape of membrane carrier proteins. • Some Na + rushes in = depolarization. Inside of cell becomes locally + instead of –. • Local ion channels close, no more Na + ions enter. • Active transport then pumps Na + back out. This is called repolarization. Cell regains "-" charge inside, "+" charge outside. • If initial depolarization is not enough, don't get action potential = threshold effect. • Time required for re-establishing polarization = 5 millisec. This is called the refractory period: nerve can't fire again until recovered.

13. Transmission of Nerve Impulses • The neuron membrane is Excitatory. • Once one area depolarizes, spreads to adjacent areas, travels down length of neuron. • Since stimulus starts at dendrite, travel is down neuron axon. • Neuron continues to fire => sequence of action potentials, all same size. • More stimulation = more frequent firing; less stimulation = less frequent firing

14. Transmission From One Cell to Another • Messages travel within the neuron as an electrical action potential. • The space between two cells is known as the synaptic cleft. • To cross the synaptic cleft requires the actions of neurotransmitters. • Neurotransmitters are stored in small synaptic vessicles clustered at the tip of the axon.

15. Neurotransmitters • More than 60 different types of neurotransmitters known. • Example: Neuromuscular Junction. Neurotransmitter =Acetylcholine (AcCh) — also found in many other brain nerve junctions. • As AcCh released across synapse, binds to muscle cell membrane. Causes depolarization of muscle cell membrane, which passes down muscle cell. Releases Ca ++ ions, which triggers muscle contraction. • If AcCh not removed, membrane remains depolarized, no more impulses. So must quickly get rid of AcCh. • Enzyme Acetylcholinesterase is present in synapse, breaks down AcCh. Allows up to 1000 impulses/sec to cross junction. • Some other neurotransmitters: • Norepinephrine: stress response. • Dopamine: used only by certain neurons that coordinate muscles. • Serotonin: used by neurons involved in perception, sleep, emotions. • Endorphins: body’s own morphine. • GABA: involved in inhibitory synapses (may be as much as 90%).

16. Blockers of synaptic transmission Some "poisons" interfere with transmission: • Curare : drug from poison toad in central America (used on poison darts). • Parathion : an insecticide used in agriculture • Tabun : nerve gas, used by Iraq during Iraq-Iran war in 1980's • Botulin toxin: the most poisonous substance known, produced by bacterium Clostridium botulinum. Interferes with transmission from motor neurons to muscle cells, causes flaccid paralysis.

17. Synapse

18. Transmission of a Nerve Impulse • Arrival of the action potential causes some of the vesicles to move to the end of the axon. • Vesicles empty (discharge) their contents into the synaptic cleft. • Released neurotransmitters diffuse across the cleft, and bind to receptors on the other cell's membrane. • Causing ion channels on that cell to open. • Some neurotransmitters cause an action potential, others are inhibitory

19. Parkinson's Disease • A deficiency of the neurotransmitter dopamine. • Progressive death of brain cells increases this deficit. • Causing tremors, rigidity and unstable posture. • L-dopa is a chemical related to dopamine that eases some of the symptoms (by acting as a substitute neurotransmitter) but cannot reverse the progression of the disease.

20. Peripheral Nervous System • The Peripheral Nervous System (PNS) contains only nerves and connects the brain and spinal cord (CNS) to the rest of the body. • Cranial nerves in the PNS take impulses to and from the brain (CNS). • Spinal nerves take impulses to and away from the spinal cord.

21. Components of the PNS • Two main components of the PNS • Sensory (afferent) pathways that provide input from the body into the CNS. • Motor (efferent) pathways that carry signals to muscles and glands (effectors). There are two major subdivisions of the PNS motor pathways: the somatic and the autonomic. • Most sensory input carried in the PNS remains below the level of conscious awareness. • Input that does reach the conscious level contributes to perception of our external environment.

22. Central Nervous System • The Central Nervous System (CNS) is composed of the brain and spinal cord. • The brain is composed of three parts: the cerebrum (seat of consciousness), the cerebellum, and the medulla oblongata (these latter two are "part of the unconscious brain").

23. Vertebrate Evolutionary Trends • Increase in brain size relative to body size. • Subdivision and increasing specialization of the forebrain, midbrain, and hindbrain. • Growth in relative size of the forebrain, especially the cerebrum, which is associated with increasingly complex behaviour in mammals.

24. The Brain • Medulla oblongata is closest to the spinal cord, and is involved with the regulation of heartbeat, breathing, vasoconstriction (blood pressure), and reflex centers for vomiting, coughing, sneezing, swallowing, and hiccuping. • The hypothalamus regulates homeostasis. It has regulatory areas for thirst, hunger, body temperature, water balance, and blood pressure. • The midbrain and pons are also part of the unconscious brain. • The thalamus serves as a central relay point for incoming nervous messages, acts as a switching center for nerve messages • The cerebellum is the second largest part of the brain, after the cerebrum. It functions for muscle coordination and maintains normal muscle tone and posture. The cerebellum coordinates balance • The cerebrum coordinates sensory data and motor functions. The cerebrum governs intelligence and reasoning, learning and memory.

25. Subdivisions of the Brain • Forebrain: - consists of the diencephalon and cerebrum - thalamus and hypothalamus are the parts of the diencephalon. - cerebrum, the largest part of the human brain, covered by a thin layer of gray matter known as the cerebral cortex, - divide the cortex into four lobes: occipital, temporal, parietal, and frontal

26. The Major Brain Areas and Lobes

27. The Hind and Midbrain • The brain stem is the smallest and from an evolutionary viewpoint, the oldest and most primitive part of the brain. • The brain stem is continuous with the spinal cord, and is composed of the parts of the hindbrain and midbrain. • The medulla oblongata and pons control heart rate, constriction of blood vessels, digestion and respiration. • The midbrain consists of connections between the hindbrain and forebrain. Mammals use this part of the brain only for eye reflexes. • The cerebellum is the third part of the hindbrain, but it is not considered part of the brain stem. • Functions of the cerebellum include fine motor coordination and body movement, posture, and balance. This region of the brain is enlarged in birds and controls muscle action needed for flight.

28. The Spinal Cord • The spinal cord runs along the dorsal side of the body and links the brain to the rest of the body. • Vertebrates have their spinal cords encased in a series of (usually) bony vertebrae that comprise the vertebral column

29. The Brain and Drugs • Some neurotransmitters are excitory, such as acetylcholine, norepinephrine, serotonin, and dopamine. • Some are associated with relaxation, such as dopamine and serotonin. • Dopamine release seems related to sensations of pleasure. Endorphins are natural opioids that produce elation and reduction of pain, as do artificial chemicals such as opium and heroin. • Neurological diseases, for example Parkinson's disease are due to imbalances of neurotransmitters.

30. Effects of Different Drugs • Drugs are stimulants or depressants that block or enhance certain neurotransmitters. • Dopamine is thought involved with all forms of pleasure. • Cocaine interferes with uptake of dopamine from the synaptic cleft. Alcohol causes a euphoric "high" followed by a depression. • Cocaine is from the plant Erthoxylon coca. Inhaled, smoked or injected. Cocaine users report a "rush" of euphoria following use. Following the rush is a short (5-30 minute) period of arousal followed by a depression. Repeated cycle of use terminate in a "crash" when the cocaine is gone. Prolonged used causes production of less dopamine, causing the user to need more of the drug.

31. Heroin • Heroin is a derivative of morphine, which in turn is obtained from opium, the milky secretions obtained from the opium poppy, Papaver somniferum. • Heroin is usually injected intravenously, although snorting and smoking serve as alternative delivery methods. • Heroin binds to ophioid receptors in the brain, where the natural chemical endorphins are involved in the cessation pain. • Heroin is physically addictive, and prolonged use causes less endorphin production. • Once this happens, the euphoria is no longer felt, only dependence and delay of withdrawal symptoms