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Low Risk GTD Phase III trial

Low Risk GTD Phase III trial. Schema. Pulse Act-D 1.25 mg/m2 every 2 weeks IV. Low Risk GTD WHO Score* 0-6 * WHO 2002 scoring. Randomize. Multiday Methotrexate Institutional preference of Either 0.4mg/kg daily x5 IV q 2weeks or CC 8 day regimen with leukovorin rescue.

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Low Risk GTD Phase III trial

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  1. Low Risk GTD Phase III trial

  2. Schema Pulse Act-D 1.25 mg/m2 every 2 weeks IV Low Risk GTD WHO Score* 0-6 * WHO 2002 scoring Randomize Multiday Methotrexate Institutional preference of Either 0.4mg/kg daily x5 IV q 2weeks or CC 8 day regimen with leukovorin rescue Statistical considerations: power to test if experimental (MTX) arm is superior based on GOG 174: based on CR .70 for control arm and .80 for experimental arm power 90%

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