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Chapter 10:. Patterns of Inheritance. Thinking Time!!!!!!!!!. Why is it, in some cases, that two brown-eyed parents have all brown-eyed children, and in other cases two brown-eyed parents have some brown-eyed children and some blue-eyed children?
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Chapter 10: Patterns of Inheritance
Thinking Time!!!!!!!!! • Why is it, in some cases, that two brown-eyed parents have all brown-eyed children, and in other cases two brown-eyed parents have some brown-eyed children and some blue-eyed children? • What do you think would be the result of a cross between a red flower and a white flower?
1. The Blending Hypothesis: • Predicts that offspring appearances will be blends of the phenotypes of their parents. 2. The Particulate Hypothesis (Mendel): • One copy of each factor is inherited from each parent. • The factors remain intact and do not physically blend together. + red white all pink + + red white red white
Genetic Vocabulary: • Trait:Variation of a particular character. • Ex: eye color is a character, • Hybrids:The offspring of 2 different true-breeding species. • Monohybrid cross:a pairing in which the parents differ in only one (mono) character. • Ex: Flower color traits while + mule
P generation:Parent plants F1 generation:The hybrid offspring F2 generation:When F1 plants self-fertilize or fertilize each other, their offspring makes up the F2 generation.
Terms need to know: • Allele: The different forms of genes. • Organisms have two alleles for each trait, one from each parent. • Dominant: appear to hide other traits. • capital letters • Recessive: can be hidden in one generation and then appear in the next. • lower-caser letters • Phenotype - the way an organisms’ genes express themselves (physical type, description) • either short, tall, purple, white, & etc • Genotype - the gene type of an organism (genes, letters) • TT, Tt, tt ABCDEFGH abcdefgh
Homozygous vs. Heterozygous In pea plants, • Homozygous - 2 alleles are the same. • homozygous dominant • 2 dominant genes : PP • homozygous recessive • 2 recessive genes : pp • Heterozygous – 2 alleles are different. • 1 dominant gene and 1 recessive gene: Pp. is dominant over
Gregor Mendel • Often called the "Father of Genetics” • Performed many experiments with plants, mostly garden peas. • His 1st step: identify true-breeding plant. • 2nd step: He crossed true-breeding plants that had two distinct traits. ?
Mendel’s First Experiment: ¾of plants are purple ¼ of plants are white
Mendel’s Results: • He examined the inheritance patterns of 7 different pea-plant characters. • For each character, one of the two parent traits disappeared in the F1, but reappeared in ¼ of the F2 generation.
The Testcross: • It is not possible to predict the genotype of an organism with a dominant phenotype. • It could be homozygous dominant PP or heterozygous Pp. • A test cross can determine the identity of the unknown allele.
Writing Genotypes from phenotypes: For Height: tall (T) is dominant and short (t) is recessive. • 1. homozygous dominant for height • Answer: TT • 2. heterozygous for height • Answer: Tt • 3. homozygous tall • Answer: TT • 4. recessive for height • Answer: tt • 5. heterozygous tall • Answer: Tt
Writing phenotypes from genotypes: For Height: tall (T) is dominant and short (t) is recessive. For Flower color: red (R) is dominant and white (r) is recessive. • 6. TT • Answer: homozygous dominant, tall • 7. tt • Answer: homozygous recessive, short • 8. Tt • Answer: heterozygous, tall • 9. Rr • Answer: heterozygous, red • 10. rr • Answer: homozygous recessive, white
Activity Time: The Coin Activity
When tossing one penny, what is the probability of getting one head? • When tossing one penny, what is the probability of getting one tail?
When tossing two pennies, what is the probability of getting one head and one tail?
Punnett Squares • It shows the possible outcomes for the Phenotypes of the individual.
Predicting Genotypes & Phenotypes • In pea plants, • Cross: homozygous tall X homozygous short is dominant over Tall Short
Step 1: • Write down the genotypes of each parent • ABCDEFGH dominant traits • abcdefgh recessive traits • Homozygous tall: • Homozygous short: TT tt
Step 2: • Draw a Punnett square • Write the gametes of one parent across the top and the other parent along the side T T t t
Step 3: • Fill in each box of the Punnett square • Capital letter goes 1st T T t T t T t t T t T t
Step 4: • List the possible genotypes and phenotypes of the offspring. • Possible genotypes: • Possible phenotypes: Tt Tall
Results Parent 1: T T Parent 2: t T t T t t T t T t
Results • Each of the offspring has a ____ /4 or _____% chance of showing ______ genotype. • Since T (tall) is dominant over t (short). Therefore, each of the offspring has a ____/4 or _____% chance of being __________. 4 100 Tt 4 100 tall
Practice Time: Key: brown eyes (B) is dominant, blue eyes (b) is recessive Homozygous dominant X Heterozygous • Genotypes: BB & Bb is dominant over Questions: • Phenotype of offspring? • Genotype of offspring? • Phenotypic ratio: • Genotypic ratio: B B all brown Bb BB BB BB & Bb 4 brown: 0 blue Bb Bb 2 BB: 2Bb
Your Turn In humans, is dominant over Questions: • Phenotype of offspring? • Genotype of offspring? • Phenotypic ratio: • Genotypic ratio: brown & blue BB, Bb & bb 1 BB: 2 Bb: 1 bb 3 Brown: 1 blue heterozygous brown X heterozygous brown
Dihybrid Cross • In one dihybrid cross experiment, Mendel studied the inheritance of seed color and seed shape. is dominant over Yellow (Y) green (y) is dominant over Round (R) wrinkled (r)
Dihybrid cross: • Mendel crossed true-breeding plants that had yellow, round seeds (YYRR) with true-breeding plants that has green, wrinkled seeds (yyrr). • The first parent could only produce RY gametes. The other could only produce ry gametes. • The union of these gametes results in RrYy.
Dihybrid Cross: Four classes of gametes (YR, Yr, yR, and yr) are produced in equal amounts. • Which results in 16 equally probable ways in which the alleles can combine in the F2 generation. • Phenotypic ratio - 9:3:3:1
Intermediate Inheritance: • In Mendel’s pea crosses, the F1 offspring always looked like the dominant homozygous parent. • Because the recessive phenotype required two recessive alleles. • But, for some characters of organisms, neither allele is dominant intermediate inheritance. YY yellow Yy yellow yy green Dominant
Intermediate Inheritance: • Heterozygous F1 generation hybrids do not show the phenotype of the dominant allele or the recessive allele but somewhere in between. • For example, in a particular breed of chickens called Andalusians, black and white offspring produce blue F1 hybrid offspring. • Because neither the black nor white is dominant, capital or lower case letters are not used. • Instead a C for color is paired with a superscript B for black or W for white. CBCW CWCW CB CB black white blue
CB CB X CWCW The predicted phenotypes in F2 are 1 black: 2 blue: 1 white CBCW CBCW CBCW CWCW CB CB
Multiple Alleles: • Codominant: both alleles are expressed • The gene for human blood type expresses four phenotypes: • A, B, AB or O. • The alleles IA and IB are codominant and the i allele is recessive to both.
The letters refer to two carbohydrates, designated A and B, which are found on the surface of red blood cells.
FYI: • Type O-negative blood does not have any antigens. It is called the "universal donor" type because it is compatible with any blood type. • Type AB-positive blood is called the "universal recipient" type because a person who has it can receive blood of any type.
Polygenic inheritance • When a single phenotype results from the expression of two or more genes. • For instance, phenotypes like high blood pressure are not the result of a single "blood pressure" gene with many alleles. • The phenotype is an interaction between a person's weight, cholesterol level, kidney function, smoking, and probably lots of others too.
The Importance of Environment • An individual’s phenotype depends on environment as well as genes. • In human, nutrition influences height, exercise affects build, and exposure to sunlight darkens skin. • The product of a genotype is generally not a single defined phenotype, but a range of possibilities influenced by the environment.
Chromosome Theory of Inheritance: • It states that: • Genes are located on chromosomes. • Homologous Chromosomes separate during meiosis so that alleles are segregated. • Chromosomes under go segregation and independent assortment during meiosis.
Mendel’s Law of Genetics: 1. Alleles are different forms of the same gene that segregate during gamete formation (Law of Segregation) 2. Alleles of different genes segregate independently (Law of independent assortment)
Sex-linked Genes • Located on a sex chromosome • In humans, most sex-linked genes are found on the X chromosome, which is much larger than the Y chromosome. • Discovered by Thomas Hunt Morgan.
P: Morgan mated a white-eyed male fly with a red-eyed female fly. F1: All the F1 offspring hadred eyes.
X F1: Then, he bred the F1 offspring together. XRXrfemale XRYmale He got the classical 3:1 phenotypic ratio.However, none of the flies with white eyes were female.He concluded that the gene involved is only on the X chromosome. F2: