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WHY TITAN WORKS AGAINST RESTENOSIS?

Discover why Titanium-Nitride-Oxide is effective in reducing restenosis through scientific evidence from cell, animal, and human models.

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WHY TITAN WORKS AGAINST RESTENOSIS?

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  1. WHY TITAN WORKS AGAINST RESTENOSIS?

  2. WHY TITAN WORKS AGAINST RESTENOSIS ? INTRODUCTION THE CELL MODEL THE ANIMAL MODEL THE HUMAN CONCLUSION

  3. WHY TITAN WORKS AGAINST RESTENOSIS ? INTRODUCTION Why can we be so confident that Titanium-Nitride-Oxide is ACTIVE ?

  4. WHY TITAN WORKS AGAINST RESTENOSIS ? INTRODUCTION Because the scientific data available at 3 different levels is UNQUESTIONABLE -The Cell model, -The Animal model, -The Human.

  5. WHY TITAN WORKS AGAINST RESTENOSIS ? THE CELL MODEL 1-Titanium-Nitride-Oxide is ACTIVE inhibiting PLATELET ADHESION. • « …On the titanium oxide films no platelet aggregation was found, almostno red blood cells were damaged, and almost no fibrin was found on the surface. However, all three characteristics were found on the surface of Carbon… » Journal of Biomedical material 1998 – page 128

  6. WHY TITAN WORKS AGAINST RESTENOSIS ? THE CELL MODEL • « …However, all three characteristics were found on the surface of Carbon… » Beyond pointing out the rationale behind the efficacy of Titanium coating this study, shows that BIOCOMPATIBILITY as such is not a very significanyt factor in reducing restenosis. Carbon a highly biocompatible material widely used in implants has none of the positive effect of Titanium coating. It explains why so many biocompatible coatings have failed to demonstrate any efficacy in the fight against restenosis.

  7. WHY TITAN WORKS AGAINST RESTENOSIS ? THE CELL MODEL • « …Local tissue response to metal implants is closely related to the amount and toxicity of the corrosion product. Minimal fibrosis is typically observed around Titanium alloys, whereas fibrous layers as much as 2 mm thick are encountered with Co-Cr and especially, steel implants… » Journal of Cardiology 1997 – page 386 2 -Titanium-Nitride-Oxide is ACTIVE minimising inflammatory response acting as a BARRIER Against Cr, Co and Ni ions RELEASE « …Stainless steel implants can cause inflammatory hypersensitivity reactions and allergic reactions to metal, which lead to a fibroproliferative response around the implant. A fibroproliferative and inflammatory response is also characteristically seen in restenotic tissue within coronary stents… » The Lancet 2000 – page 1897

  8. WHY TITAN WORKS AGAINST RESTENOSIS ? THE ANIMAL MODEL Titanium Nitride Oxide Vs 316Lin porcine model47% reductionof neointimal hyperplasia REMINDER ! Sirolimus (Cypher) in porcine model50 % reductionof neointimal hyperplasia

  9. WHY TITAN WORKS AGAINST RESTENOSIS ? THE HUMAN 33 55% 15 Titanium Nitride Oxide Binary Restenosis Circulation TITANIUM NITRIDE OXIDE BMS

  10. WHY TITAN WORKS AGAINST RESTENOSIS ? THE HUMAN 33 55% 15 TITANIUM NITRIDE OXIDE BMS

  11. WHY TITAN WORKS AGAINST RESTENOSIS ? CONCLUSION Today the only stents that have proven to be active on restenosis reduction are : Cypher Taxus Titan2

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