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Assessment and Management of Polytrauma Patients with Head Injuries

Explore epidemiological aspects, pathophysiology, evaluation, management, surgery considerations, Glasgow Coma Scale, and prognosis of head injuries in polytrauma patients. Learn about ICP monitoring, ICU management, prognosis factors, and outcome prediction methods.

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Assessment and Management of Polytrauma Patients with Head Injuries

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  1. Assessment, Management and Decision Making in the Treatment of Polytrauma Patients with Head Injuries Roman A. Hayda, MD Original Author March 2004; Revised July 2006, November 2010

  2. Epidemiologic Aspects • 80,000 survivors of head injury annually • 125,000 children <15yo head injured annually • 40-60% of head injured patients have extremity injury • 32,000-48,000 head injury survivors with orthopaedic injuries annually

  3. Overview • Pathophysiology • Initial evaluation • Prognosis • Management of Head Injury • Orthopaedic Issues • Operative vs. nonoperative treatment • Timing of surgery • methods • Fracture healing in head injury • Associated injuries • Complications

  4. 2nd hit 1st hit • 1st hit: Head • mechanical insult to brain tissue • blunt or penetrating • 2nd hit: Head • release of inflammatory mediators • Hypoxia • Acidosis • Coagulopathy • 1st hit: body • mechanical insult • chest, abdomen • extremities • 2nd hit: body • systemic inflammation • SURGERY

  5. Evaluation • ATLS—ABC’s • History • loss of consciousness • Physical exam • Glasgow Coma Scale • Radiographic studies • CT Scan

  6. Evaluation • Must exclude head injury by evaluation if • history of loss of consciousness • significant amnesia • confusion, combativeness • Cannot be simply attributed to drug or alcohol use • neurologic deficits on exam of cranial nerves or extremities

  7. Physical Exam • Exam of head and cranial nerves for lateralizing signs • dilated or sluggish pupil(s) • Extremities • unilateral weakness • posturing • decorticate (flexor) • decerebrate (extensor)

  8. Eye opening: 1-4 Motor response: 1-6 Verbal response: 1-5 Glasgow Coma Scale

  9. Eye opening Spontaneous 4 To speech 3 To pain 2 None 1 Glasgow Coma Scale

  10. Motor response Obeys commands 6 Purposeful response to pain 5 Withdrawal to pain 4 Flexion response to pain 3 Extension response to pain 2 None 1 Glasgow Coma Scale

  11. Verbal response Oriented 5 Confused 4 Inappropriate 3 Incomprehensible 2 None 1 Glasgow Coma Scale

  12. Glasgow Coma Scale • Sum scores (3-15) • <9 considered severe • 9-12 moderate • 13-15 mild* • Modifiers—xT–ifintubated (Best score possible 11T) xTP – if intubated and paralyzed (Best score possible is 3TP) • Done in the field but best in trauma bay following initial resuscitation

  13. Radiographic Studies Frontal Contusion • CT scan • required in ALL cases EXCEPT: • LOC is brief AND • patient can be serially examined • lesions • focal--epidural, subdural hematoma, contusions • diffuse--diffuse axonal injury • Plain films • useful only to detect skull fracture but in the trauma setting wastes time

  14. Treatment • Initial • Intubation if unresponsive or combative to give controlled ventilation • pharmacologic paralysis • after neurologic exam is completed • Blood pressure and O2 saturation monitoring • keep systolic > 90 mm Hg • 100% O2 saturation

  15. ICP Monitoring • Indications • severe head injury (GCS < 9) • abnormal head CT or • Coma >6 hrs • Intracranial hematoma requiring evacuation • Delayed neurologic deterioration from mild to moderate (GCS>9) to severe (GCS < 8) • Requirement for prolonged ventilation • Pulmonary injury, surgery etc.

  16. O2 saturation 100% Mean arterial pressure 90-110 mm Hg ICP < 20 mm Hg Cerebral Perfusion Pressure (CPP=MAP-ICP) >70 mm Hg ICU Management Goals

  17. HCT~ 30-33% PaCO2= 35±2 mm Hg CVP= 8-14 mm Hg avoid dextrose IV maintain euthermia or mild hypothermia ICU Adjuncts

  18. Factors Influencing Prognosis • Age • Younger pts have greatest potential for survival and recovery • 61-75% mortality if over 65 • 90% mortality in elderly with ICP >20 and coma for more than 3 days • 100% mortality if GCS < 5, uni- or bilateral dilated pupils, and age over 75 • Bottom line: survival and recovery not predictable except in old pts • Treat presuming recovery

  19. Factors Influencing Prognosis • Hypotension--50% increase in mortality with single episode of hypotension • Hypoxia • Delay in treatment • prolonged transport • surgical delay when lateralizing signs present Potentially controllable!!

  20. Outcome • Glasgow Outcome Score: • 1-dead • 2-vegetative • 3-cannot self care • 4-deficits but able to self care • 5-return to preinjury level of function

  21. Outcome Prediction • Glasgow scale (post resuscitation) 44-66% accuracy in determining ultimate outcome • 39% with an initial GCS of < 5 made functional recovery • CT based scoring (Marshall Computed Tomographic score) only 71% accurate

  22. Outcome Prediction • Serum markers (S-100B) • Accuracy of 83% (Woertgen, J Trauma, 1999) • Good sensitivity in moderate to severe injury even with extracranial injury (Savola, J Trauma, 2004) • May be elevated in 29% fx pts without head injury (Unden, J Trauma, 2005) Clinical utility not defined

  23. Prognosis • Significant disability @ 1 yr • Disability even in “mild” injury • Glasgow cohort: 742 pts with 71% follow-up • Rate of combined severe and moderate disability similar among groups (48%, 45% and 48%) • Age >40, previous head injury, comorbidities increased disability (Thornhill, BMJ, 2000)

  24. Prognosis of the SeverelyHead Injured Patient • Gordon (J Neurosurg Anes ’95) • 1,294 pts with severe injury(GCS <9) at 10 year follow-up • 55% good recovery • 19% significant disability • 7% vegetative • 19% mortality • Sakas (J Neurosurg ‘95) • 40 pts with fixed and dilated pupils • 55% younger than 20 years made independent functional recovery • 25% mild to moderate functional disability • 43% mortality

  25. Orthopaedic Issues in the Head Injured Patient • Role in resuscitation • pelvic ring injury • open injuries • long bone fractures • Treatment methods and timing • Associated injuries • Complications

  26. Initial Surgery in the Head Injured is Damage Control Surgery

  27. Damage Control Orthopaedics • Goal • Limit ongoing hemorrhage, hypotension, and release of inflammatory factors • Limit stress on injured brain • Initial surgery • <1-2 hrs • limit surgical blood loss

  28. Damage Control Orthopaedics • Methods • Initial focus on stabilization • External fixation • Limited debridement • Limited or no internal fixation or definitive care • Delayed definitive fixation (5-7 days)

  29. Resuscitation: Role of Orthopaedics • Goal: limit ongoing hemorrhage and hypotension • pelvic ring injury-- external fixation reduced mortality from 43% to 7% (Reimer, J Trauma, ‘93) • open injury--limit bleeding • long bone fracture--controversial

  30. Long Bone Fracture in the Head Injured Patient • Early fixation (<24 hours) well accepted in the polytrauma patient • In the head injured patient early fixation may be associated with • hypotension – elevated ICP • blood loss/coagulopathy • hypoxia • Advocates of early and delayed treatment

  31. Early Osteosynthesis • Hofman (J Trauma ‘91): • 58 patients with a GCS < 7 • lower mortality and higher GOS with operative treatment within 24 hours • Poole ( J Trauma ‘92): • 114 patients with head injury • delayed fixation did not protect the injured brain • McKee (J Trauma ’97): • 46 head injured with femur fractures matched with 99 patients without fracture • no difference in neurologic outcome or mortality

  32. Early Osteosynthesis • Bone (J Trauma ‘94): • in 22 patients (age <50) with a GCS 4-5 • 13.6% (early fixation) vs 51.3% (delayed fixation) mortality rates • Starr (J Orthop Trauma ‘98): • 32 pts with head injury • 14 early, 14 delayed, 4 nonoperative • delayed fixation associated with 45X greater pulmonary complications but did not affect neurologic complications

  33. Early Osteosynthesis • Kalb (Surgery ‘98): • 123 patients, head AIS > 2, 84 early, 39 late fixation • early group had increased fluid requirement but no other difference in mortality or complication • emphasized the role of appropriate monitoring • Scalea (J Trauma ‘99): • 171 patients, mean GCS 9, 147 early, 24 late fixation • early fixation no effect on length of stay, mortality, CNS complications

  34. Delayed Osteosynthesis • Reynolds (Annals of Surg ‘95): • Mortality 2/105 patients, both early rodding (<24 hrs) • one due to neurologic and the other pulmonary deterioration • Jaicks (J Trauma ‘97): • 33 patients with head AIS > 2; 19 early fixation 14 late • early group required more fluid in 48 hrs (14 vs 8.7 l); more intraoperative hypotension (16% vs 7%); lower discharge GCS (13.5 vs 15)

  35. Delayed Osteosythesis • Townsend (J Trauma ‘98): • 61 patients with GCS < 8; • hypotension 8 X more likely if operated < 2 hrs and 2 X more likely when operated within 24 hrs • no difference noted in GOS

  36. Advances in Care of Head Injured • ICP monitoring • Evolution of anesthetic agents • Improvement in neuroanesthetic techniques Allow for safer surgery in the head injured

  37. Fracture Care • Ultimate neurologic outcome continues to be difficult to predict • Presume recovery • Avoid treatments that may compromise neurologic outcome • All interventions must strive to reduce musculoskeletal complications inherent in the head injured patient • Management decisions made in conjunction with trauma/neurosurgical team

  38. Algorithm for Fracture care in Head injured • Severe Head injury (GCS<9) or unstable pt DAMAGE CONTROL SURGERY Convert to definitive at 5+ days • Mild head injury (GCS 13-15); stable pt Consider EARLY TOTAL CARE • Intermediate head injury Determined by pt stability; complexity of surgery

  39. Operative Fracture Care • Surgery is often optimal form of fracture treatment in the head injured polytrauma patient • Advantages • Alignment • Articular congruity • Early rehabilitation • Facilitated nursing care Galleazzi, ulna and olecranon fx with compartment syndrome

  40. Operative Fracture Care • Perform early surgery when appropriate • MUST minimize • hypotension • hypoxia • elevated ICP • Consider temporary methods (external fixation) • Fixation must be adequate • Patient may be non compliant • “accelerated” healing cannot be relied upon • use • appropriate • monitors

  41. Nonoperative Fracture Management • Treatment of choice when • nonoperative means best treat that particular fracture • operative risks outweigh potential benefits • Modalities • splint • brace • cast • traction • Caveat • device must be removed periodically to inspect underlying skin for decubiti

  42. Bone Healing in the Head Injured Patient • Humoral osteogenic factors are released by the injured brain • Exuberant callus MAY be seen • Soft tissue ossification is common • Ultimate union rate of fractures inconsistently affected

  43. Fracture Healing with Head Injury • Cadosch, JBJS-A, 2009 • Case matched series of 17 pts with avg GCS 5.6, treated with IM nail • Union 2X faster; 37-50%> callus; serum induced osteoblast proliferation • Boes, JBJS-A, 2006 • Experimental model of 43 rats with IM nailed femur fx +/- head injury • More fx stiffness in head injury cohort • Serum of head injured rats promoted stem cell proliferation

  44. Complications • Heterotopic Ossification • up to 89-100% incidence periarticular injury with head injury • Contractures • Malunion Recurrent elbow dislocation secondary to extensor posturing and heterotopic ossification

  45. Heterotopic Ossification • Associated with ventilator dependency • Use approaches/techniques less associated with H.O. • Prophylaxis • XRT • Indocin • Excision

  46. Contractures • Occurs due to spasticity/posturing • Effects • Inhibits restoration of function • Complicates nursing care • Predisposes to decubitus ulcers

  47. Contractures • Treatment: • Prevention • splinting/positioning • early physical and occupational therapy • Established • serial casting • manipulation • surgery • nerve blocks

  48. Associated Injuries • Normal methods of clinical and radiologic assessment may not apply in the head injured patient • C spine injury • Occult fractures and injury

  49. 13-15 1.4% 9-12 6.8% <9 10.2% C Spine Injury • Incidence increases with increasing severity of head injury Demetraiades, J Trauma, ’00 • Evaluation more difficult • Optimal protocol for evaluation and management controversial C spine injury Incidence GCS

  50. C Spine Injury • Minimum requirement • Cervical collar • CT entire C spine with reconstructions • Adjuncts • MRI • Difficult in vent patient • May over call injury • “Dynamic” flexion extension radiographs in the obtunded patient • Safety and reliability not established

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