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Sympathetic Ophthalmitis. Annie Mathai, Rajeev K Reddy, Hemant S Trehan, Ritesh Narula Smt.Kanuri Santhamma Retina Vitreous Centre, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad. Ocular History. 48 year old man
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Sympathetic Ophthalmitis Annie Mathai, Rajeev K Reddy, Hemant S Trehan, Ritesh Narula Smt.Kanuri Santhamma Retina Vitreous Centre, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad
Ocular History • 48 year old man • 7-2007: decreased vision OS following injury with stone 17 days earlier • Diagnosed as globe rupture with uveal prolapse • Underwent excision of prolapsed uveal tissue and corneo-scleral tear repair
28th July 2007: First Presentation • VA: OD - 20/20, OS - no PL • OD - normal • OS - red eye • Corneo-scleral sutures • Irregular AC • AC details not clear • Soft eye • No fundus view OS
Ultrasonography OS • Funnel RD • Choroidal thickening • Peripheral choroidal detachment
Diagnosis & management • OD - normal • OS - status post corneo-scleral tear repair, RD, pre-phthisical eye • Treatment OS: • Prednisolone acetate eye drops 2 hourly • Ofloxacin eye drops 4 hourly • Atropine eye drops 3times/day
9th September 2007: Second Presentation • Pain, redness, decreased vision OD x 3 days • Seen elsewhere with shallow AC, raised IOP • Diagnosed as angle closure glaucoma OD • Underwent OD:YAG peripheral iridectomy • Started on topical and systemic steroids (20mg)
9th September 2007: Second Presentation • VA: OD - 2/60, OS - no PL • Anterior segment OD • AC: 1-2+ cells, 1+ flare • Sluggishly reacting pupil • 3 attempted PIs • IOP - 10 mm Hg • OS findings same as before
9th September 2007: Second Presentation • Fundus examination OD • No vitreous cells • Shallow serous detachment at macula • Diagnosed as CSCR
9th September 2007: B-scan & OCT • Localised RD on B-scan & OCT • No choroidal thickening on B-scan
9th September 2007: Diagnosis • Acute central serous chorioretinopathy precipitated by steroids • Anterior uveitis secondary to PI • Systemic steroids discontinued • Topical steroids continued • Called for review after 3 days
12th September 2007: 3 days later • Visual acuity OD - 6/18 • AC - 2+ cells, 1+ flare • No vitreous cells • Fundus - shallow serous RD • Topical steroids continued • Called for review after 2 weeks
19th September 2007: 1 week later • Seen in emergency • Sudden decrease of vision OD • Visual acuity - 1/60 • Fresh kps, 2+ cells, 2+ flare • Fundus - serous RD • Yellow subretinal lesions
Clinical diagnosis • Symathetic ophthalmitis • B-scan to look for choroidal thickness • Fluorescein angiography
Ultrasonography • Echo free vitreous cavity • Localised shallow RD • No choroidal thickening
Fluorescein angiography 27 sec 1min 9 sec 2 min 10 sec 4 min 40 sec
Fluorescein angiography • Pin-point hyperfluorescence • Hyperfluorescence increases in late phase
Final diagnosis & management • Sympathetic ophthalmitis • IV Methyl prednisolone 1 gm daily x 3 days • Followed by oral prednisolone • OU: Pred acetate eye drops 2 hourly • OU: Homatropine eye drops 3 times/day
Response to treatment (OD) • On 4th day visual acuity improved to 6/18 • In 10 days visual acuity was 6/6 • Serous RD completely resolved • Topical and oral steroids continued • Also started on Azothioprine 50 mg BD
Response to treatment - serous RD Prior to treatment Following treatment
Last follow-up Visual acuity - 6/6
Conclusions • Bilateral ocular involvement following open-globe injuries .......... • High alert for sympathetic ophthalmitis • Fluorescein angiography is a crucial investigation to confirm sympathetic ophthalmitis