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Naturally Programmed Cell Death, Apoptosis, and Cancer

Naturally Programmed Cell Death, Apoptosis, and Cancer. Folder Title: Apoptose. or . April 12, 2005. TtlApop. What happened to your webbed feet? You guys are dethpicable. DaffyDuc. God and Michelangelo. Creation by Subtraction. Evolution: Selective Reproduction

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Naturally Programmed Cell Death, Apoptosis, and Cancer

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  1. Naturally Programmed Cell Death, Apoptosis, and Cancer Folder Title: Apoptose or ... April 12, 2005 TtlApop

  2. What happened to your webbed feet? You guys are dethpicable. DaffyDuc

  3. God and Michelangelo Creation by Subtraction Evolution: Selective Reproduction Selective Death Subtract

  4. Selective Cell Death in Normal Development and Normal Organismic Functioning Developmental Remodelling • Tadpole to Frog • Human Fetal Remodelling • Immunological Self-Tolerance Normal Physiology • Post-Lactation Breast Involution • Menstruation • Normal Immune T-Cell Killing NormApop

  5. Necrosis vs Apoptosis Apoptosis Condensed Nuclear Fragments Shrunken Cytoplasm Membrane Blebs (Apoptotic Bodies) Phagocytosis without Inflammation Necrosis Clumped Chromatin Swelling of Organelles Cell Distension Membrane Disruption Inflammation Kill&Die

  6. Apoptotic Cell. Ruddon, 3rd Ed. Fig. 10-7 ApoCell

  7. Membrane Blebs on a Cell Undergoing Apoptosis from Scientific American, December, 1996 ApoBlebs

  8. DNA Lysis into "DNA Ladder". DNA from Apoptotic Cell. From Ruddon, 3rd Ed., Figure 10-8 ApoDNA

  9. Genetic Control of "Genetically Programmed Cell Death" Apoptosis Gene Effect on Apoptosis Blocks Stimulates Wild-type Stimulates Mutant Blocks Stimulates Cellular Location of Protein Product Mitochondrial Membrane Nuclear Envelope Endoplasmic Reticulum Nucleus Nucleus Cell Membrane bcl-2 myc p53 p53* APO-1/ FAS ApoGenes

  10. Programmed Cell Death

  11. Exogenous Genetic Suppressors of Apoptosis Adenovirus E1b Oncoprotein Ras v-abl compox crm a gene product ExoApop1

  12. Exogenous Inducers of Apoptosis Cytotoxic T-Lymphocyte Attack on Target Cells Loss of Growth Factors Loss of Responses from Neighboring Cells DNA-Directed Anti-Neoplastic Agents ExoApop2

  13. More Exogenous Inducers of Apoptosis(from Ruddon, 3rd Ed., p. 397) Differentiation Signals Removal of Growth Factors or Required Hormones Exposure to Transforming Growth Factor B (TGF-B) Tumor Necrosis Factor (TNF) Glucocorticoids (Immune-modulating Corticosteroids) DNA-damaging Antineoplastic Agents Environmental Toxins Agents Stimulating Ca Influx (Calcium Ionophores) Cytoskeletal-directed Microtubule Disruptors Microfilament-directed Cytochalasin B Inhibits formation of Apoptotic Bodies, but not apoptosis itself ExoApop3

  14. Normal T-Cell Activation by Antigen-Presenting Cells.(from Sci. Am., Dec, 1996) TCellAct

  15. Activated T-Cell Down-regulation via FAS Cell-Surface Protein and Ligand Binding to FAS. (from Sci. Am., Dec., 1996) TCelDown

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