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Inhalants

Inhalants. Psychology 3506. Introduction. OK, now this is depressing…. Solvents, paints, nail polish remover, gasoline, lighter fluid… Late 50’s the media and cops picked up on glue sniffing, which seemed to have increased the amount of glue sniffed…. Same with aerosols in the 1970s

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Inhalants

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  1. Inhalants Psychology 3506

  2. Introduction • OK, now this is depressing…. • Solvents, paints, nail polish remover, gasoline, lighter fluid… • Late 50’s the media and cops picked up on glue sniffing, which seemed to have increased the amount of glue sniffed…. • Same with aerosols in the 1970s • Now it is gasoline

  3. Administration • Sniffing • Huffing • Swallowing • Cloth can make sure you get fresh air • Bag concentrates it • From aerosol can too

  4. Absorption, Distribution and Excretion • Absorbed into lungs • Passed quickly to brain • Concentration in blood approaches concentration in air • Fatty tissue get the most (due to high lipid solubility) • Brain • liver

  5. Absorption, Distribution and Excretion • Concentrations also drop quickly • Through the lungs • More blood flow, faster reduction • Toluene for example is metabolized in the liver though, most not exhaled • Liver creates metabolites that may be toxic

  6. Neurophysiology • Effects seem similar to alcohol and tranquilizers • Enhance GABA • Enhance glycine • Attenuate NMDA receptor for glutamate • Seems to affect DA in mesolimbic dopamine system, but how, we dunno

  7. Behavioural Effects • Like alcohol • Hallucinations • Seizures • Stupor • Death • Probably impairs driving

  8. Effects, continued • Tolerance, maybe • Withdrawal, maybe • Psychotic behaviour • Cancer • Kidney damage • FSS? • OD

  9. Prevention and Treatment • Nasty additives • Education • Treatment is really tough • They have lots of other problems usually • May take many attempts

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