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The latest news from the Older Australian Twins Study (OATS)

The latest news from the Older Australian Twins Study (OATS). Brain & Ageing Research Program Information Day 12 February 2011 Andrea Lammél. Outline. Why study elderly twins … ? Pathways influencing cognition Variability in memory performance Preliminary results Further analyses.

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The latest news from the Older Australian Twins Study (OATS)

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  1. The latest news from the Older Australian Twins Study (OATS) Brain & Ageing Research Program Information Day 12 February 2011 Andrea Lammél

  2. Outline • Why study elderly twins … ? • Pathways influencing cognition • Variability in memory performance • Preliminary results • Further analyses

  3. Why study elderly twins …? • Seeking to identify and characterise the genetic and environmental sources of individual differences • Genetic component • Additive (A) • Environmental component • Shared environment (C) • Unique environment (E)

  4. Classical twin design • Classical twin design: comparison of identical (MZ) and non-identical (DZ) twins reared together • MZ: share 100% of their genetic material • DZ: share 50% of their genetic material

  5. Path analyses A= Additive genetic C = Shared environment E = non-shared environment

  6. Pathways influencing cognition

  7. Variability in memory performance

  8. Twin studies in the elderly(aged ≥ 65 +)

  9. Preliminary results: Cognition

  10. Brain volume analyses Younger brain … … older brain

  11. Brain structures analyses

  12. Further analyses • Establishing gene-environmental relationships (path analyses): • cognitive functioning • specific brain structures and volume • medical and psychiatric conditions • lifestyle factors • Genetic analysis • New gene discovery

  13. Thank you ! OATS collaborators Queensland Institute of Medical Research (QIMR) National Ageing Research Institute (NARI) ------------ Swedish Adoption/Twin Study of Ageing (Sweden) Mayo Clinic Study of Aging (USA) University of Bristol (UK)

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