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Surbhi D Joshi 1 ,

OUTCOME OF PLAQUE BRACHYTHERAPY IN OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN). Surbhi D Joshi 1 , Santosh G Honavar 1 , Manju Meena 1 , Milind N Naik 1 , Geeta K Vemuganti 2 , Vijay Anand P Reddy 3

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Surbhi D Joshi 1 ,

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  1. OUTCOME OF PLAQUE BRACHYTHERAPY IN OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN) Surbhi D Joshi1, Santosh G Honavar1, Manju Meena1, Milind N Naik1, Geeta K Vemuganti2, Vijay Anand P Reddy3 1 Department of Ocular Oncology,LV Prasad eye Institute, Hyderabad.2 Department of Ophthalmic Pathology, LV Prasad eye Institute, Hyderabad.3 Department of Radiation Oncology, Apollo Cancer Hospital, Hyderabad.

  2. I have no financial interests or relationships to disclose Financial Disclosure

  3. Introduction • Commonest ocular surface tumor in Asia • Excision + cryotherapy : Recurrence rate <5% • Factors affecting recurrence • Residual tumor • Aggressive HPE variant • Systemic factors (HIV, Xeroderma Pigmentosa) • Episcleral radiation : Plaque Brachytherapy • Promising Results • Organ and function salvage

  4. Study Method • Prospective interventional case series • January 2004- December2009 Study Aim • To evaluate Ru-106 plaque brachytherapy in the management of OSSN

  5. Demographics & Treatment Details • Total patients: 21 • Males: 12 • Mean Age: 49.28 • (range, 33-71)yrs • Indications for Episcleral Plaque: • Residual (Excision base + on HPE) • Recurrent Ru-106 Round Plaque for all patients Minimum follow up: 1 year Maximum follow up: 6 years

  6. Episcleral fixity & UBM • On clinical examination episcleral fixity was noted in 10(47.6%) patients • On UBM, suspicious scleral involvement was seen in 5 patients

  7. Results • Complications : • Scleral necrosis -1 • Corneal epithelial defect – 1 • Recurrence Management : • Enucleation • Exenteration 19.1% PRE HPE POST

  8. Conclusions • Ru-106 plaque brachytherapy is a safe & effective option in the management of residual or recurrent OSSN with scleral infiltration • It provides for good tumor control, & eye & vision salvage

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