Careers at the drug discovery interfaces

Dec 05, 2012

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Set-Up. Drugs are a $300 bil. businessSingle drug revenues average >$500 mil.Sustaining ~10 marketed drugs requires 1 new drug per yearAverage drug market profitability is 10 years post launch to generics 10 yr development time. Current Industry Environment. Pharmaceutical costs remain ~10% of t

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Careers at the drug discovery interfaces

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Presentation Transcript

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS. BY. Dr. BASAVARAJ K. NANJWADE. Department of Pharmaceutics K L E UNIVERSITY JN MEDICAL COLLEGE BELGAUM – 590010 E-mail: bknanjwade@yahoo.co.in. DRUG.

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Drug discovery and development

Drug discovery and development. Ian Hughes, i.e.hughes@leeds.ac.uk Objectives of next 5 lectures: you will: be aware of why/how new drugs are discovered know the processes involved in drug discovery and development see where pharmacologists/bioscientists may contribute

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Drug Design / drug discovery

Drug Design / drug discovery. Jerome Baudry Assistant Professor BCMB UT/ORNL Center for Molecular Biophysics. 2 previous incarnations: Research faculty at UIUC Research scientist at Transtech Pharma, Inc. . Drug Design / drug discovery. What’s a drug?

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Drug Discovery

Drug Discovery. The use of solid phase combinatorial chemistry and parallel synthesis. Problems with Traditional Synthesis. 1 chemist 1 molecule Can only make one molecule at a time Each synthesis very time consuming Multistep syntheses have loss at each step

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Process of Drug Discovery

Process of Drug Discovery. History …… Plant products pre-date the rise of modern medicine …… Use of opium, licorice, ephedra, marijuana, camellia, alcohol, digitalis, cocoa, quinine etc… …… First discovered was morphine (opium), which was found to be alkaline (1817)

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Drug Discovery and Development

Drug Discovery and Development. How are drugs discovered and developed?. Choose a disease Choose a drug target Identify a “bioassay” bioassay = A test used to determine biological activity. Find a “lead compound”

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Drug Discovery Programs at BMS

LC-MS in Drug Discovery Timothy V. Olah, Ph.D. Director, Bioanalytical Research Pharmaceutical Research Institute Bristol-Myers Squibb Company timothy.olah@bms.com University of Connecticut 20 February 2007. Drug Discovery Programs at BMS.

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DRUG DISCOVERY

DRUG DISCOVERY. Random Search e.g., buying paintbrush, mop, hammer, gluestick, nail, etc. etc. for hanging a picture frame on the wall Rational Design e.g., buying a nail for hanging the frame Combinatorial Search

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Modern drug discovery techniques

Modern drug discovery techniques. Drugs were discovered through identifying the active ingredient from traditional remedies or by unexpected discovery.

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Drug Discovery and Development

Drug Discovery and Development. How are drugs discovered and developed?. Basic Steps. Choose a disease Choose a drug target Identify a “bioassay” bioassay = A test used to determine biological activity. Find a “lead compound”

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Drug Discovery & Development

Drug Discovery & Development. PHC 323. LEC. 9. II-Improving metabolism :. I-Making drugs more resistant to chemical and enzymatic degradation. 1)- Steric shields Some functional groups are more susceptible to chemical and enzymatic degradation than other.

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Ligand-based drug discovery

Ligand-based drug discovery. No a priori knowledge of the receptor What information can we get from a few active compounds. Drug-likeness: what makes a drug a drug?. Lipinski’s “rule of 5”: most drugs have less than two violation of the following rules: * ≤ 10 hydrogen bond acceptors

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The Science of Drug Discovery

The Science of Drug Discovery. Rich Whitley April 21, 2011. The Many Faces of Clinical Research. Natural History Study The impact of congenital cytomegalovirus infection on hearing Evaluation of a Diagnostic Assessment of an Intervention Benefits of drug eluting stent placement

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Drug Design / drug discovery

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Drug Discovery: Proteomics, Genomics

Drug Discovery: Proteomics, Genomics. Philip E. Bourne Professor of Pharmacology UCSD pbourne@ucsd.edu 858-534-8301. Agenda. Where my perspective comes from The interplay between omics, IT and drug discovery The omics revolution Changes in IT and open science and software licensing

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18 Drug Discovery Process

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Drug discovery informatics market

Drug Discovery Informatics Market is expected to rise from its initial estimated value of USD 1.85 billion in 2018 to an estimated value of USD 4.34 billion by 2026, registering a CAGR of 11.27% in the forecast period of 2019-2026.

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Drug Discovery

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Careers at the drug discovery interfaces

Careers at the drug discovery interfaces

Presentation Transcript

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

Drug discovery and development

Drug Design / drug discovery

Drug Discovery

Process of Drug Discovery

Drug Discovery and Development

Drug Discovery Programs at BMS

DRUG DISCOVERY

Modern drug discovery techniques

Drug Discovery and Development

Drug Discovery &amp; Development

Ligand-based drug discovery

The Science of Drug Discovery

Drug Design / drug discovery

Drug Discovery: Proteomics, Genomics

Drug Discovery Process

18 Drug Discovery Process

DRUG DISCOVERY AND DEVELOPMENT

Antifungal drug discovery.

Drug discovery informatics market

Drug Discovery

Drug Discovery & Development