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Impact of ASPAN’s Evidence-based Clinical Practice Guideline for the Prevention and/or Treatment of PONV/PDNV. Corey R. Peterson DNP, CRNA, Lisa Stephens, DNP, CRNA, Marguerite Murphy, DNP, RN, Vallire Hooper, PhD, RN, CPAN, FAAN, Jan Odom- Forren , PhD, RN, CPAN, FAAN.
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Impact of ASPAN’s Evidence-based Clinical Practice Guideline for the Prevention and/or Treatment of PONV/PDNV Corey R. Peterson DNP, CRNA, Lisa Stephens, DNP, CRNA, Marguerite Murphy, DNP, RN, Vallire Hooper, PhD, RN, CPAN, FAAN, Jan Odom-Forren, PhD, RN, CPAN, FAAN
Postoperative & Postdischarge Nausea and Vomiting (PONV/PDNV) • 53 million ambulatory surgeries annually National Health Statistics Report (2009) • 30% - 50% incidence of PDNV (16 – 26.5 million incidents) Apfel et al., (2004) • Threats associated with PONV/PDNV − Pt dissatisfaction − Increased pain − MI − Wound dehiscence − Aspiration −Delayed discharge − Delayed return to function -Increased costs − Noncompliance w/discharge instruction Apfel et al., (2002)
Postoperative & Postdischarge Nausea and Vomiting (PONV/PDNV) • Is a common anesthesia complication Apfel et al., (1999) • Is the most feared anesthesia complication by patients Awad (2006) • Is a complex physiologic phenomena Hornby, (2001) • Is largely preventable and treatable Habib et al, (2004)
PONV/PDNV • PONV – first 24 hrs post – op • PDNV – after discharge • Predictable risk factors exist for PONV/PDNV Apfel et al.(2002) • Efficacious pharmacological interventions exist for PONV/PDNV Gan et al., (2007); Odom-Forren et al., (2006)
Evidenced-Based Clinical Practice Guidelines (EBCPG) • In 2006 the American Society of PeriAnesthesia Nurses (ASPAN) published EBCPG for the prevention and/or treatment of PONV/PDNV ASPAN (2006) • ASPAN guidelines base the number of interventions given on a patient’s risk of PONV/PDNV • ASPAN guidelines are • Evidenced-based • Patient focused • Multidisciplinary • Cost conscience
Problem Statement • PONV/PDNV is an ongoing complication • Efficacious interventions exist to prevent and/or manage PONV/PDNV • High quality EBCPG exist to guide anesthesia providers in the prevention and/or management of PONV/PDNV • No information exists regarding the level of adoption of these EBCPG by anesthesia providers
From The Literature • EBCPG are effective and efficacious tools to improve healthcare delivery • Implementation of EBCPG is a complex process • PONV/PDNV is a common, significant complication of general anesthesia • High quality EBCPG exist to prevent and treat PONV/PDNV
Areas Of Inquiry • What is the degree of adoption of the recommendations of the ASPAN PONV/PDNV guidelines • Is there a relationship between the appropriate application of the ASPAN guidelines and the incidence of PDNV • Is there a relationship between the incidence of PONV and the incidence of PDNV • Is there a cost savings associated with the use of the ASPAN guidelines
Methodology • Secondary data analysis (N=94) • Primary Study • Primary Aim – to determine independent predictors of PDNV • Study Design • Multi-site prospective survey • No prescribed treatment regimen • Targeted sample size ~2000
Interventions Recommended vs. Administered Pearson’s product-moment correlation (r) = 0.21, N = 94, p= 0.004
Discussion • Poor degree of adoption of the guidelines • 68% NOT treated according to the guidelines • 32% treated according to guidelines • Majority of patients received a single intervention • Higher risk tended to be undertreated • Lower risk tended to be overtreated • Pearson product-moment correlation • r=0.21 N=94 p=.004
Discussion • Poor guideline adoption is consistent with recent research • McMenamin et al.(2010). • Chamie et al. (2011). • Shirvani et al. (2011). • Bhattacharyya et al. (2010). • Kooij et al. (2010). • Franck et al. (2010). • White et al (2008).
Discussion • Poor adoption of the ASPAN guidelines made it impossible to determine the efficacy of the guidelines • Trends • Patients with higher risks received more interventions • Patients who received more interventions had a lower incidence of PONV & PDNV
Discussion • Incidence of PDNV was over 60% • Incidence of PDNV was 2 – 3 times the incidence of PONV • No additional interventions for PDNV • Short duration of action of antiemetics • Longer reporting period for PDNV
Discussion • Institutional antiemetic costs Ondansetron $0.32 Metaclopromide $0.29 Diphenhydramine $0.60 Promethazine $0.46 Dexamethazone $0.83 Compazine $1.89 Scopolamine Patch $10.14 (A. Barnett, personal communications, September 5, 2011) • Institutional cost of antiemetic drug are insignificant in relation to other health care cost
Practice Implications • Given • Poor adoption of even simple, well supported EBCPG • The more antiemetics given the lower the incidence of PONV/PDNV • Current first-line antiemetics have excellent safety profiles and negligible costs • Is it time to revise the ASPAN guidelines to recommend every patient receives the maximum number of antiemetics regardless of their risk?
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