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GOOD MORNING. CASE PRESENTATION AND DISCUSSION ON ACUTE APPENDICITIS. by Michael Angelo L.Suñaz Pre-resident Ospital ng Maynila Medical Center. GENERAL DATA. R.P. 35/M. CHIEF COMPLAINT. generalized abdominal pain. HISTORY OF PRESENT ILLNESS.
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CASE PRESENTATION AND DISCUSSION ON ACUTE APPENDICITIS by Michael Angelo L.Suñaz Pre-resident Ospital ng Maynila Medical Center
GENERAL DATA R.P. 35/M
CHIEF COMPLAINT • generalized abdominal pain
HISTORY OF PRESENT ILLNESS • 6 days PTA - grade 9/10 colicky epigastric pain with radiation to the lower abdomen - followed by 3 episodes of vomiting - abdominal distention - dysuria
HISTORY OF PRESENT ILLNESS • 5 days PTA - on and off abdominal pain of the same characteristics with radiation to the back - 3 episodes of vomiting - (+) BM
HISTORY OF PRESENT ILLNESS • 3 days PTA - persistence of condition - consultation - unrecalled diagnosis and medications
HISTORY OF PRESENT ILLNESS • 1 day PTA - (+) diarrhea and abdominal distention - consultation and the FM OPD - prescribed Lactulose 30cc h.s. and Fibrosine, 1 sachet in the am
HISTORY OF PRESENT ILLNESS • 1 day PTA - CBC: mild leukocytosis 10,400/mm3 (5,000-10,000) Serum K+: hypokalemia 2.7mmol/L (3.6-5.0)
HISTORY OF PRESENT ILLNESS • DOA - persistence of his condition prompted consultation at the Surgery ER with subsequent admission
PAST MEDICAL HISTORY • No known comorbidities
FAMILY HISTORY • No known heredofamilial diseases
PERSONAL/ SOCIAL HISTORY • nonsmoker; no history of alcoholic beverage intake
REVIEW OF SYSTEMS • No decrease in appetite; no fever or chills
PHYSICAL EXAMINATION • G/S: conscious; coherent; not in cardiorespiratory distress; ambulatory • V/S: BP: 110/70 HR: 82 RR: 20 Temp:370C • HEENT:pink conjunctivae; anicteric sclerae; no TPC; no NAD; no CLAD • C/L: SCE; CBS • CVS: NR, RR, no murmurs
PHYSICAL EXAMINATION • Abdomen: globular; HABS; (+) direct tenderness on RUQ; no fluid wave; (+) muscle guarding on RLQ • Extremities: no edema, atrophy, or cyanosis
SALIENT FEATURES • 35/M • 9/10 epigastric pain with radiation to lower abdomenradiation to the back • abdominal distention • vomiting • dysuria • (+) BM diarrhea
SALIENT FEATURES • HABS • direct tenderness on RUQ • muscle guarding on RLQ • hypokalemia • leukocytosis
Generalized abdominal pain inflammatory Non-inflammatory Ileus 20 hypokalemia 20 AGE appendicitis
PARACLINICAL DIAGNOSTIC PROCEDURE • Do I need a paraclinical diagnostic procedure? NO.
GOALS OF TREATMENT • Relieve cause of abdominal pain • Least morbidity and mortality
PRE-OP PREPARATION • Psychological support • Screen for previous medical problem • Optimize patient’s condition • Consent • Preparation of materials
OPERATIVE TECHNIQUE AND INTRA-OP FINDINGS • Exploratory laparotomy, appendectomy for acute perforative appendicitis with peritonitis • Evacuated >100cc of bloody peritoneal fluid • Meckel’s diveticulum noted at the antimesenteric portion of the small bowel 30 cm from the ileo-cecal valve; nonerythamatous, no signs of diverticulitis
OPERATIVE TECHNIQUE AND INTRA-OP FINDINGS • Serosal tear noted 80cm from the ileo-cecal valve • Repair of tear with silk 4-0 • Release of Ladd bands • Washing of peritoneal cavity • Patient tolerated the procedure well
FINAL DIAGNOSIS • acute perforative appendicitis with peritonitis
POST-OP CARE • 1st POD • Abdomen: distended, soft, nontender, pain on operative site, no rigidity, no guarding • (+) flatus • UO: 45cc/hr in 240 • NPO • D5LR 1L x 60
POST-OP CARE • 1st POD • Maintain NGT and IFC • Cefuroxime 75mg TIV q80 Metronidazole 500mg TIV q80 Famotidine 40mg TIV q120 RTC while on NPO Diclofenac Na+ in 8cc IVF as slow IV push q120 x 3 doses Tramadol 50mg IV q60 x 6 doses • O2at 3-4 Lpm for DOB
POST-OP CARE • 2nd POD • Continue IVF and IV meds • NGT pulled out • encourage ambulation • Moderate to high back rest • Paracetamol 300mg TIV q40 RTC for 240 then q40 prn for temp > 38.50C
POST-OP CARE • 3rd POD • (+) BM • IFC pulled out • Abdominal binder applied • General liquids • IVF and IV meds continued
POST-OP CARE • 4th POD • Abdomen: no d/c from operative sit, good coaptation and granulation, nontender, no pain • (+) watery stool • (+) frequent flatus • Soft diet • Increase OFI
POST-OP CARE • 5th POD • IVF and IV meds to consume • Start Metronidazole 500mg qid p.o. Cefuroxime 500mg tid p.o. • DAT with SAP
POST-OP CARE • 6th POD • MGH
DISCUSSION • Vermiform appendix - a blind-ending tubular, worm-like structure arising from the inferior part of the cecum -in adults, a normal vermiform appendix varies in length from 5-35 cm (average 8 cm). • Appendicitis - an acute inflammation of the appendix
APPENDICITIS • Pathophysiology - obstruction of the appendiceal lumen is the primary cause distention of the appendix due to accumulated intraluminal fluid. - obstruction may be due to: • Fecalith (most common) • Strictures • Parasite infection • Kinks • Adhesions • Foreign bodies
APPENDICITIS - ineffective lymphatic and venous drainage bacterial invasion of appendiceal wall perforation spillage of pus peritonitis
APPENDICITIS • Early stage appendicitis - obstruction of the appendiceal lumen mucosal edema, ulceration, diapedesis of bacteria, distention of the appendix stimulation of the visceral afferent nerve fibers visceral periumbilical or epigastric pain lasting 4-6 hours.
APPENDICITIS • Suppurative appendicitis - increasing intraluminal pressures exceed capillary perfusion pressure obstructed lymphatic and venous drainage bacterial and inflammatory fluid invasion of the tense appendiceal wall transmural spread of bacteria -inflamed serosa of the appendix comes in contact with the parietal peritoneumclassic shift of pain to the right lower quadrant (RLQ)
APPENDICITIS • Gangrenous appendicitis - due to intramural venous and arterial thromboses
APPENDICITIS • Perforated appendicitis - persisitent ischemia infarction perforation
APPENDICITIS • Phlegmonous appendicitis - inflamed or perforated appendix is walled off by the greater omentum or by bowel loops
APPENDICITIS • Clinical presentation • colicky abdominal pain initially located periumbilically or epigastrically then subsequently shifts to the RLQ (50%), where it becomes progressively more severe. • Nausea (61-92%), vomiting, anorexia (74-78%), and low-grade fever --When vomiting occurs, it almost always follows the onset of pain. • Diarrhea or constipation is observed in 18% of patients.
APPENDICITIS • Clinical presentation • Rebound tenderness (96%), pain on percussion, rigidity, and guarding • RLQ pain with palpation of the left lower quadrant (Rovsing sign), RLQ pain with hyperextension of the right hip (psoas sign), and RLQ pain with internal rotation of the flexed right hip (obturator sign) rarely are present with acute appendicitis.
APPENDICITIS • Laboratory findings • Leukocytosis (>10,000/mm3) is observed in 80% of patients. • high level C-reactive protein (>0.8 mg/dL) with leukocytosis and neutrophilia are the most sensitive laboratory findings, with a sensitivity of approximately (97-100%; Graffeo, 1996; Gronroos, 1999). Therefore, the probability of acute appendicitis is low in the absence of these 3 laboratory findings. • A urine test may be performed to exclude urinary tract infection as the cause.
INTERVENTION • Immediate (emergent) appendectomy - historically, recommended for all patients with appendicitis, whether perforated or not
INTERVENTION • Percutaneous or transrectal drainage - used in conjunction with IV antiboitics in patients with perforated appendicitis with mild symptoms and localized abscess or phlegmon on abdominopelvic CT scans -if the patient's symptoms, WBC count, and fever satisfactorily resolve, therapy can be changed to oral antibiotics and the patient can be sent home.
INTERVENTION • Delayed (interval) appendectomy - performed 4-8 weeks after percutaneous or transrectal drainage - may not be necessary unless patient presents with recurrent symptoms
REFERENCES Craig, S. Acute appendicitis. Available through the worldwide web (http://www.emedicine.com). 24 October 2006. Incesu, L and Taylor, C. Appendicitis. Available through the worldwide web (http://www.emedicine.com). 10 June 2004.