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Signaling Involved in Liver Regeneration

Signaling Involved in Liver Regeneration. >100 immediate early genes identified Cytokine Mediated Pathway IL6, TNF Gene transcription Induced Proliferation Growth Factor Mediated Pathway HGF, EGF, TGF, VEGF Termination Suppressors of Cytokine Signaling SOCS3.

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Signaling Involved in Liver Regeneration

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  1. Signaling Involved in Liver Regeneration • >100 immediate early genes identified • Cytokine Mediated Pathway • IL6, TNF • Gene transcription • Induced Proliferation • Growth Factor Mediated Pathway • HGF, EGF, TGF, VEGF • Termination • Suppressors of Cytokine Signaling • SOCS3 "Liver Repopulation and Stem Cells." Aliment Pharmacol Ther 18 (2003): 473-80.

  2. Growth Factors Involved in Liver Regeneration Mohammed, F.F., and Khokha, R. Thinking outside the cell: proteases regulate hepatocyte division. Trends in Cell Biology, 15, 555, 2005.

  3. Hepatocyte Growth Factor • Synthesized proby non-parenchymal cells • -Stellate • -Paracrine and Endocrine effects • -pro-HGF precursor activated by proteases • -binds to c-MET receptor • -HGF/c-met signaling is essential for • cell cycle entry after PH • Multiple Effects • -morphogenic, -motogenic -mitogenic Conrad, Dennis R. "HGF Pathway." Sigma Aldrich. Sigma Aldrich Co. <http://www.sigmaaldrich.com/area_of_interest/life_science/pathfinder/pathway_maps/hgf_pathway.html>.

  4. C-MET (HGF Receptor) -α,β heterodimer with tyrosine kinase activity -dimerization after ligand binding -associates with a multiprotein complex involved in downstream signal transduction Herveg, Jean-Pierre. "C-Met Signaling." 2003. ICampus. <http://www.icampus.ucl.ac.be/courses/sbim2520/document/genemol/pictures/c-met/c-met.html>.

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