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(a)

(a). Sir2. Sum1. Hst1. Promoter. ORF. ORF inside peak. 3’ end of ORF. Intergenic. ( b ). ( c ). 100. 70. Sir2. Hst1. 60. 80. 50. 60. # of Tags. 40. **. 40. Sir2. Hst1. 22. 30. 28. 153. 20. 20. **. 29. **. **. 20. Sum1. Hst2. 26. 4. 80. 70. 15. Sum1. 60.

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(a)

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  1. (a) Sir2 Sum1 Hst1 Promoter ORF ORF inside peak 3’ end of ORF Intergenic (b) (c) 100 70 Sir2 Hst1 60 80 50 60 # of Tags 40 ** 40 Sir2 Hst1 22 30 28 153 20 20 ** 29 ** ** 20 Sum1 Hst2 26 4 80 70 15 Sum1 60 18 10 # of Tags 50 40 5 30 0 (d) ENO2 PDC1 CDC19 500 bp 500 bp 500 bp [0- 1093] Input [0- 666] Sir2 [0- 500] Hst1 [0- 565] Sum1 [0- 84] Hst2 YHR176W YHR175W YHR174W YHR172W YAL037C-A YAL037W YAL038W YLR040C YLR043C YLR044C YLR045C (e) PDC1 ENO2 Relative IP 5’ end middle 3’ end 5’ end middle 3’ end

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