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Cancer II

Cancer II. Six ways of losing the remaining good copy of a tumor suppressor gene. When proto-oncogene becomes overactive it becomes an oncogene. Myc Gene Amplification. Mitogens stimulate G1-Cdk and G1/S-Cdk activities. Ocogene collaboration in transgenic mice. Viruses May cause Cancer.

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Cancer II

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  1. Cancer II

  2. Six ways of losing the remaining good copy of a tumor suppressor gene

  3. When proto-oncogene becomes overactive it becomes an oncogene

  4. Myc Gene Amplification

  5. Mitogens stimulate G1-Cdk and G1/S-Cdk activities

  6. Ocogene collaboration in transgenic mice

  7. Viruses May cause Cancer Papillomavirus causes warts and subverts the control of cell division

  8. Pap smears normal abnormal invasive

  9. How papillomaviruses are thought to give rise to cancer of the uterine cervix

  10. Activation of cell proliferation by DNA tumor virus

  11. Sequence of genetic changes underlying the development of a colorectal carcinoma

  12. Each tumor will contain a different set of mutations

  13. Effect of ionizing radiation on normal and cancer cells

  14. Cell Junctions, Cell Adhesion, and the Extracellular Matrix Chapter 19

  15. Cross sectional view of intestinal wall

  16. Tracer molecules can not cross tight junctions

  17. Structure of tight junction

  18. Electron Micrograph of tight junctions

  19. Model of tight junction

  20. Claudins are main component of sealing strands

  21. Anchoring junctions in an epithelium

  22. Anchoring junctions are formed by proteins

  23. Cadherins connect actin filaments of different cells

  24. DVD Clip 82

  25. Desmosomes and hemidesmosomes both link to intermediate filaments

  26. Cadherins also bind intermediate filaments together

  27. Integrins link extracellular matrix to cytoskeleton

  28. Size of gap junction channel can be determined with fluorescent molecules of different sizes

  29. A Gap junction connexon is made up of 6 transmembrane connexin subunits

  30. Images of gap junctions

  31. The permeability of gap junctions can be regulated dopamine treatment reduces permeability of gap junctions to a fluorescent dye

  32. Summary of cell junctions found in the cell

  33. Summary of cell junctions found in the cell

  34. In plant cells plasmodesmata perform many of the same functions as gap junctions

  35. View of plasmodesmata

  36. Structure of Cadherin – responsible for cell to cell adhesion in vertebrate cells

  37. Ca2+ is required to establish cell to cell connection through cadherin

  38. Three mechanisms that mediate cell-cell adhesion cadherins least common

  39. Cadherins allow cells to sort themselves

  40. Catenins join cadherins to actin filaments in adherence junctions

  41. Summary of junctional and non-junctional adhesive mechanisms

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