Course: Immunopathology and Immunotherapeutics

1. Course: Immunopathology and Immunotherapeutics By Dr. SheebaMurad Mall

2. Recommended Books • Essentials of Clinical Immunology by Helen Chapel, ManselHaeney, SirajMisbah and Neil Snowden • Immunology by Kuby, 2011 • Basics in Immunology by Lichtmann and Abdul Abbass

3. Course Contents: • The basis of immunology, Antigen recognition and response of immune system • Tolerance: immunological principles of tolerance: central versus peripheral tolerance, role of regulatory T cells, natural killer T cells, dendritic cells • Primary immunodeficiencies of lymphocytes, phagocyte disorders, complement disorders • Proliferation disorders of immunologic cells: lymphomas, plasma cell eosinophilia, mastocytosis • Systemic disorders with immunopathologic key mechanisms: rheumatoid arthritis, systemic lupus erythematosus, rheumatic fewer and other conditions • Organ specific immunopathology: diabetes melitus, autoimmune thyroid disease, myastenia gravis, multiple sclerosis, autoimmune hemolytic anemia • Allergic diseases: asthma, anaphylactic syndrome, insect venom allergy – • Immune evasion mechanisms in infections: Tuberculosis, EBV-infection, Lyme disease • Autoimmune response and immune tolerance, Priming regulatory t cells and antigen specific suppression of autoimmune diseases, Peripheral t cell regulation and autoimmunity, Antiergotypic regulation of immune response • Immune mediated inflammatory disorders: role of TNF, role of other inflammatory pathways, identification of therapeutic targets • Allergy and asthma: role of inflammatory cells and immune cells; role of mediators; therapeutic targets • Immunotherapy: overview of immunotherapies (small molecules, biologicals): principles, indications, side effects: T cell therapy, Non-T cell therapy, Use of dendritic cells in immunotherapy , heat shock proteins • Solid Tumor Immunology and immunotherapy

4. First sessional 20% • Second sessional 20% • Quiz and Assignment 10% • Terminal 50%

5. The basis of immunology, Antigen recognition and response of immune system

6. Terms in relation to Immunity • Immunity is defined as resistance to disease • “Immunity” derives from the latin word immunis, meaning exemption from military service, tax payments or other public services • The state of exemption or protection from infectious disease • The collection of cells, tissues and molecules that mediate resistance to infections is called an immune system • The study in relation to the immune system is termed as Immunology • The coordinated reaction of these cells and molecules to infectious microbes is the immune response

7. The immune system recognizes infection and induces protective responses: immunological recognition immune effector functions Immune regulation immunological memory

8. Lymphoid organs

9. Basic terms used in Immunology • Innate immunity • Adaptive immunity • Humoral immunity • Cell-mediated immunity • Antigen • Epitope • Hapten • Superantigen • TLR • PRRs • MHC molecules • Immunological memory • Antigen presenting cells