The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care

1. The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care

2. Drug delivery devices (V3) Slow Peripheral Compartment (V2) Rapid Peripheral Compartment (V1) Central Compartment Bar-coded Bolus Syringes Pharmacokinetic Models (Ve) Effect Site Infusion Pumps Pharmacodynamic Modeling

4. Syroid N, Anesth 2002;96:565-575

13. (b) (a) [prop] (ug/ml) [remi] (ng/ml) [remi] (ng/ml) [prop] (ug/ml) (d) (c) [remi] (ng/ml) [prop] (ug/ml) [remi] (ng/ml) [prop] (ug/ml)

14. Return of Responsiveness

16. Laryngoscopy Mertens and Kern

18. Effect Path

21. Bankart Procedure Level of Pain/Analgesia Skin Incisions Artho-scopic Procedure Figure 2 – 10 0 20 Analgesia Level (Display) Maintenance Phase Time (min). Analgesia Level (Control)

22. Experiment 1: ResultsHeart Rate *

23. Experiment 1: ResultsBlood Pressure *

24. * * * *

29. Anesthesia Advisory Display: Real time guidance through the pharmacokinetic and interaction pharmacodynamic relationship during simultaneous administration of multiple drugs.Schumacher, Bouillon, Leibundgut, Sartori, Zbinden, ASA 2004

33. Navigation Display: FlightSim.com