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The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care. Drug delivery devices. (V 3 ) Slow Peripheral Compartment. (V 2 ) Rapid Peripheral Compartment. (V 1 ) Central Compartment. Bar-coded Bolus Syringes. Pharmacokinetic Models. (V e ) Effect Site.
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The Value of Real Time Pharmacokinetic and Pharmacodynamic Modeling in Critical Care
Drug delivery devices (V3) Slow Peripheral Compartment (V2) Rapid Peripheral Compartment (V1) Central Compartment Bar-coded Bolus Syringes Pharmacokinetic Models (Ve) Effect Site Infusion Pumps Pharmacodynamic Modeling
(b) (a) [prop] (ug/ml) [remi] (ng/ml) [remi] (ng/ml) [prop] (ug/ml) (d) (c) [remi] (ng/ml) [prop] (ug/ml) [remi] (ng/ml) [prop] (ug/ml)
Laryngoscopy Mertens and Kern
Bankart Procedure Level of Pain/Analgesia Skin Incisions Artho-scopic Procedure Figure 2 – 10 0 20 Analgesia Level (Display) Maintenance Phase Time (min). Analgesia Level (Control)
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Anesthesia Advisory Display: Real time guidance through the pharmacokinetic and interaction pharmacodynamic relationship during simultaneous administration of multiple drugs.Schumacher, Bouillon, Leibundgut, Sartori, Zbinden, ASA 2004