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»» Multi-frequency RF probe development »» HTS probe development »» MAS probe development

AMRIS Mission. • Technology Development for High Field MRI/S. »» Multi-frequency RF probe development »» HTS probe development »» MAS probe development »» Coils tailored for unique capabilities »» Microimaging at micron resolution »» Nanomaterials for multimodal imaging »» Mixture analysis.

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»» Multi-frequency RF probe development »» HTS probe development »» MAS probe development

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  1. AMRIS Mission • Technology Development for High Field MRI/S »» Multi-frequency RF probe development »» HTS probe development »» MAS probe development »» Coils tailored for unique capabilities »» Microimaging at micron resolution »» Nanomaterials for multimodal imaging »» Mixture analysis • User Program for High Field MRI/S »» A menagerie of animals (mouseelephant) »» Imaging and spectroscopy at cellular resolution »»Diffusion on a nanometer to micron scale »» Low gamma detected MRI/S »» Biophysics and structural biology »» Chemical ecology and metabolomics »» Natural products

  2. Recent Science Highlights of the AMRIS MRI/S Program • First MRI microscopy of mammalian neurons and subcellular structures • Two cover articles in NeuroImage • Imaging with direct histological characterization of nucleoli in frog ova • Development of stronger gradients and perfusion probe with Bruker • High resolution brain white matter fiber structure • Fiber tract connections between major anatomical regions • Transport models for convection-enhanced CNS delivery • Natural product identification • ~1 mL of a “defensive ooze” from a leaf insect • We found 3 related pyrazines (smells like chocolate!) • Required the 1-mm HTS probe (right before it broke…) • Gene reporter for detection of cellular LacZ expression by MRI Pre Sgal Post Sgal -LacZ as of summer 2010, mid-point in current award period

  3. Transformative (NSF NHMFL; 350k/yr) Translational (NIH, non-NHMFL NSF, Private Foundations, DOE, VA; 600k/yr and growing) • External User Program • Materials for Imaging in Extreme Environments • RF and technique development • Physical phenomena • Complex coordination of H2O • Contrast mechanisms • Accelerated acquisition techniques • Measuring and matching of magnetic susceptibility • Managing and measuring anisotropic interactions Human Imaging Animal imaging Molecular and Cellular Imaging Structural biology Complex mixture analysis Metabolomics Simple NMR Properties to Study Complex Biological Problems

  4. AMRIS Admin • Joanna Long, Director • Operates as a core facility to UF investigators as well as supports the NHMFL external user program • Part of the McKnight Brain Institute (New Director 9/1/10) • Operates under CAS; current budget of $960k • Approximately 80 grants (totaling ~$40 million annually) are supported by the AMRIS facility • NHMFL provides additional funds for three development cores which ultimately provide resources to UF: • HTS NMR probes • Novel contrast agents for use at high fields • Microimaging • NHMFL supports an RF engineer (0.5 FTE), Barbara Beck, to design coils for a variety of applications

  5. 128 MHz, 3.0 Tesla, Philips whole body MRI/S of humans/large animals 200 MHz, 4.7 Tesla, 33 cm horizontal bore MRI/S of live animals (cats, rabbits, rats, mice, etc.) 473 MHz, 11.1 Tesla, 40 cm horizontal bore MRI/S of live animals (primates, cats, rabbits, rats, mice, etc.) 500 MHz, 11.7 Tesla, 5.2 cm vertical bore Solution/solid state NMR spectroscopy of biomolecules 3x 600 MHz, 14.1 Tesla, 5.2 cm vertical bore MRI/S of superfused cells/tissues Metabolomics Solution/solid state NMR spectroscopy of biomolecules & imaging 1-mm HTS cryoprobe Microimaging coils and gradients 750 MHz, 17.6 Tesla, 8.9 cm vertical bore MRI/S of superfused cells/tissues & of live animals (e.g., mice) Solution/solid state NMR spectroscopy of biomolecules AMRIS Instrumentation

  6. AMRIS Staff • Animal MRI/S specialist: Huadong Zeng • RF Engineer: Barbara Beck (0.5 FTE) • NMR specialist: Jim Rocca • Spectrometer maintenance and microimaging: Dan Plant • 3T Operator: Joy Kidder • 3T Engineer: Dave Peterson (0.6 FTE) • Spectrometer maintenance: Kelly Jenkins • Billing and accounting: LaToya Durant

  7. Intrument upgrades Challenges for this upcoming year Expanding animal imaging user program Hiring of RF staff and/or faculty (Barbara Beck is retiring in 2011) Upgrade of 500 MHz console (1-2 years) Hiring of PhD level staff scientist in human imaging ($300k over 3 years) Expansion of 3T to 32 channels ($300k in equipment) / multi-transmit Long Term 36T and DNP user programs Outgrowing our space and meeting user demand Higher field human imaging (faculty hires)

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