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LFA-1 signaling

APC cell. HLA antigen. LFA-1. LFA-1 signaling. T cell receptor. Ser 1140. intracellular signaling. T cell. APC cell. HLA antigen. LFA-1 signaling. LFA-1. T cell receptor. Ser 1140. Talin Head. intracellular signaling.

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LFA-1 signaling

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  1. APC cell HLA antigen LFA-1 LFA-1 signaling T cell receptor Ser 1140 intracellular signaling T cell

  2. APC cell HLA antigen LFA-1 signaling LFA-1 T cell receptor Ser 1140 Talin Head intracellular signaling T cell Calpain PtdIns(4,5)P2 Talin

  3. APC cell HLA antigen PKC LFA-1 LFA-1 signaling increased affinity for ICAM-1 T cell receptor Thr 758 Ser 1140 intracellular signaling T cell

  4. APC cell HLA antigen GTP Rac1 ? GEF 14-3-3 GDP Rac1 LFA-1 signaling LFA-1 increased affinity for ICAM-1 T cell receptor Thr 758 Ser 1140 intracellular signaling LFA-1 clustering T cell actin reorganization

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