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MSmcDESPOT

MSmcDESPOT. Brain Fraction and SPM Normalized Penumbra. Updated EDSS. Updated EDSS. Updated EDSS. Updated EDSS. Brain Fraction with Prelim. GM. MWF Std. Dev. In Normals. 0–0.11 scale Clearly there is high variation in the GM, most likely due to registration imperfections

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MSmcDESPOT

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  1. MSmcDESPOT Brain Fraction and SPM Normalized Penumbra

  2. Updated EDSS

  3. Updated EDSS

  4. Updated EDSS

  5. Updated EDSS

  6. Brain Fraction with Prelim. GM

  7. MWF Std. Dev. In Normals • 0–0.11 scale • Clearly there is high variation in the GM, most likely due to registration imperfections • Similarly at edges of ventricles

  8. FLAIR Std. Dev. In Normals – Raw • Scale 0–50, not too relevant here since not quantitative • Inhomogeneity variation across normals caused a higher degree of fluctuation in the forebrain

  9. FLAIR Std. Dev. In Normals – Max Normalized • Not sure how to window properly so that the std. dev. maps are comparable • Wanted to see the image get darker -> lower std. dev. -> tighter distribution • Again the forebrain has higher variability

  10. FLAIR Std. Dev. In Normals – SPM Normalized • 0–50, same scale as Raw • Removes forebrain variability artifact • However, the image did not darken vs. Raw so the distribution did not get tighter

  11. FLAIR Std. Dev. In Normals – SPM Normalized • This is auto-windowed to the “robust range” as the max normalized one was also • Only very slight brightening vs. 0-50 range • Interpretation: • Max normalized seems to achieve a lower standard deviation across normals, this is confirmed by the larger DAWM selection

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