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Molecular Epidemiologic Research

Clinical GoalsImprove risk and prognostic prediction of diseaseProvide better understanding of pathobiology of disease. Molecular Epidemiologic Research. Scientific GoalsTo identify genetic variants associated with risk and prognosis of cancersTo identify interactions between genetic variants an

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Molecular Epidemiologic Research

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    1. Molecular Epidemiologic Research Susan Slager, PhD. Associate Professor Department of Health Sciences Research Mayo Clinic Rochester

    2. Clinical Goals Improve risk and prognostic prediction of disease Provide better understanding of pathobiology of disease Molecular Epidemiologic Research

    3. Scientific Goals To identify genetic variants associated with risk and prognosis of cancers To identify interactions between genetic variants and environmental effects that are associated with risk and prognosis of cancers Molecular Epidemiologic Research

    4. Risk Prediction Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease. Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease.

    5. Prognosis Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease. Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease.

    6. Background Chronic Lymphocytic Leukemia (CLL) is a neoplasm of the blood and is the most common adult leukemia in Caucasians Very few risk-factors for CLL have been identified family history, sex, age, and ethnicity Evidence is great that a genetic component exist to the etiology of CLL CLL has one of the highest familial risk of any cancer

    8. CLL Study Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease. Genetic association studies look at the frequency of genetic changes in a group of cases and controls to try to determine whether specific changes are associated with disease.

    9. GWAS of CLL

    10. GWAS of CLL

    11. Meta-analysis of variant on 11q24

    12. Significance Take genetic variants and model them with other factors

    13. Molecular Epidemiology Challenges Funding Large studies are needed

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