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The Evolving Treatment Landscape of Pancreatic Neuroendocrine Tumors (PNETs)

The Evolving Treatment Landscape of Pancreatic Neuroendocrine Tumors (PNETs). Activity Goals. Case 1. Case 1: Resectable PNET. WHO Classification of PNETs. Surveillance Strategy. MRI. Scenario B. Resection vs Pancreatic Enucleation. Prognosis After Resection.

christopher-travis
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The Evolving Treatment Landscape of Pancreatic Neuroendocrine Tumors (PNETs)

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  1. The Evolving Treatment Landscape of Pancreatic Neuroendocrine Tumors (PNETs)

  2. Activity Goals

  3. Case 1

  4. Case 1: Resectable PNET

  5. WHO Classification of PNETs

  6. Surveillance Strategy

  7. MRI

  8. Scenario B

  9. Resection vs Pancreatic Enucleation

  10. Prognosis After Resection

  11. Survival DurationWell- and moderately differentiated histology

  12. Significant Predictors of Recurrence in Resected Patients With Malignant PNETs

  13. Resectable PNET – Summary

  14. Case 2: Metastatic PNET

  15. Case 2: CT Scan

  16. Treatment: Metastatic PNET

  17. Classification of NETs

  18. First-line Chemotherapy: Capecitabine/Temozolomide

  19. Efficacy of Somatostatin Analogues

  20. Studies With STZ

  21. Outcomes of TMZ + CAPa vs STZ + DOXb

  22. Case 2 (cont)

  23. Case 2 (cont)

  24. Targeted Agents

  25. Case 2 (cont)

  26. Sunitinib Dosing

  27. Sunitinib: Managing Hand-Foot Syndrome

  28. Response With Second-line Everolimus

  29. Case 2 (cont)

  30. Pneumonitis

  31. Liver-Directed Therapy

  32. Radiotracer Uptake

  33. Angiogenic Pathway -- PI3K/mTOR

  34. Clinical Trials

  35. Phase 2 Study With Somatostatin-Based Radiopeptide

  36. Metastatic PNET -- Summary

  37. Abbreviations

  38. Abbreviations (cont)

  39. References

  40. References (cont)

  41. References (cont)

  42. References (cont)

  43. References (cont)

  44. References (cont)

  45. References (cont)

  46. References (cont)

  47. References (cont)

  48. References (cont)

  49. References (cont)

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