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Osteoporosis: Remodeling, Fracture Prevention, and Treatment Options

This article provides insights into osteoporosis, including the mechanisms of cortical and trabecular remodeling, the role of odanacatib in resorption pits, atypical fractures and their correlation with suppressed remodeling, stopping denosumab therapy, nonvertebral fracture prevention, and the use of strontium ranelate for improving P1NP levels.

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Osteoporosis: Remodeling, Fracture Prevention, and Treatment Options

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  1. Lippuner et al Osteoporos Int 2011;22:2487

  2. Granke et al Bone 2011;49:1020 Schaffler & Burr J Biomech 1988;21:13

  3. Cortical Remodeling is self perpetuation, trabecular remodeling is self-limiting Bjornerem et al Bone 2011;49:1125

  4. Odanacatib and Shallow resorption pits Leung et al Bone 2011;49:623

  5. Atypical fractures and suppressed remodeling Tjhia et al Bone 2011; 49:1279

  6. Stopping Denosumab Brown et al J Bone Miner Res 2011;26:2737

  7. Nonvertebral fracture prevention and antiresorptive therapy MacKey et al J Bone Miner Res 2011;26:2411

  8. Strontium ranelate and P1NP Quesada-Gomez et al Osteoporos Int 2011;22:2529

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