1 / 15

Multi-Compartment Pharmacokinetics

Multi-Compartment Pharmacokinetics. Chapters 19 and 20 http:// www.boomer.org /c/p4/. One versus Two Compartment. Rapid Equilibrium versus Slower Equilibrium. http:// www.boomer.org /c/p4/c19/c1901.html. Multi-Compartment Pharmacokinetic Model. Deviation from One Compartment Model

chun
Download Presentation

Multi-Compartment Pharmacokinetics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Multi-Compartment Pharmacokinetics Chapters 19 and 20 http://www.boomer.org/c/p4/

  2. One versus Two Compartment • Rapid Equilibrium versus Slower Equilibrium http://www.boomer.org/c/p4/c19/c1901.html

  3. Multi-Compartment Pharmacokinetic Model • Deviation from One Compartment Model • Models and Parameters • Equations • Parameter Estimation • Effect of Changing Parameters • Apparent Volumes of Distribution • Dosage Calculations • Oral Administration

  4. Multi-Compartment Pharmacokinetic Model

  5. This Equation is • The integrated equation for concentration after an IV bolus • The differential equation for concentration after an IV bolus • The integrated equation for concentration after an oral dose

  6. A Two Compartment Model becomes One when • k12 and k21 are fast • k21 is faster than k12 • CLD is fast • All of the above

  7. Varea is Calculated using • The dose and the intercept values (A and B) • The dose, AUC and beta • V1 and the microconstants

  8. Achieving and maintaining a specified Cp is easier with a 2C drug • True • False

  9. Non Compartmental Analysis • Linear (First-order) Kinetics • No Model ‘Requirement’ • New Parameters – AUMC, MRT, MAT • Faster Calculation with Spreadsheet or SAS

  10. Non Compartmental Analysis

  11. The mean residence time can be calculated as • AUMC/AUC • AUC/AUMC • AUMC2 • Dose/AUC

  12. An estimate of ka can be calculated from • AUC • AUMC • MRT • MAT

  13. Do you usually have your laptop AND phone connected to WiFi in this room? • True • False

  14. Have you had problems connecting to the WiFi in this room? • Never • Occasionally • Often

  15. Have you had problems connecting to the WiFi in this room during in-class Quiz or Exams • True • False

More Related