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Welcome Each of You to My Molecular Biology Class

Welcome Each of You to My Molecular Biology Class. Molecular Biology of the Gene, 5/E --- Watson et al. (2004). Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods. 3/29/05.

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Welcome Each of You to My Molecular Biology Class

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  1. Welcome Each of You to My Molecular Biology Class

  2. Molecular Biology of the Gene, 5/E--- Watson et al. (2004) Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/29/05

  3. Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next

  4. Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA 3/29/05

  5. CHAPTER 10 Homologous recombination at the molecular level • Molecular Biology Course

  6. All DNA is recombinant DNA. • Genetic exchange works constantly to blend and rearrange chromosomes, most obviously during meiosis, when homologous chromosomes pair prior to the first nuclear division. • During this pairing, genetic exchange between the chromosomes occurs. This exchange, classically termed crossing over, is one of the results of homologous recombination.

  7. OUTLINE • Models for Homologous Recombination (two models)** • Homologous Recombination Protein Machines (RecBCD pathway)** • Homologous Recombination in Eukaryotes (meiosis recombination, proteins) • Mating-Type Switching (a gene conversion event) • Genetic Consequences of the Mechanism of Homologous Recombination (exchange or conversion)

  8. CHAPTER 10 Homologous recombination at the molecular level 重点和难点 Topics 1 & 2 are the keys to understand homologous recombination and other topics. Completely understand two animations on your CD 3/29/05

  9. CHAPTER 9 The mutability and repair of DNA Homework Review your textbook

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