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The Open PHACTS Ecosystem Fostering a user community Open PHACTS Community Workshop June 2014

The Open PHACTS Ecosystem Fostering a user community Open PHACTS Community Workshop June 2014. Open PHACTS Mission: Integrate Multiple Research Biomedical Data Resources Into A Single Open & Free Access Point. The Open PHACTS Discovery Platform.

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The Open PHACTS Ecosystem Fostering a user community Open PHACTS Community Workshop June 2014

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  1. The Open PHACTS Ecosystem Fostering a user community Open PHACTS Community Workshop June 2014

  2. Open PHACTS Mission: Integrate Multiple Research Biomedical Data Resources Into A Single Open & FreeAccess Point

  3. The Open PHACTS Discovery Platform • Cloud-Based “Production” Level System. Secure & Private • Guided By Business Questions • Uses Semantic Web Technology But provides a simple REST-ful API for the everyone else http://dx.doi.org/10.1016/j.drudis.2013.05.008 http://dx.doi.org/10.1016/j.websem.2014.03.003

  4. Getting Started Guide: http://www.slideshare.net/pgroth/ops-developerwebinarjuly312013

  5. Drug https://dev.openphacts.org/ Target Pathway Disease (1.4)

  6. Components Workflows

  7. Our Response: • 1.4 : Batch Mode for *info methods • 1.5+ : • Further batch mode queries • Summary methods (“google maps like”)

  8. Why Use Open PHACTS?Adding Further Value

  9. Directly Working With Data Owners

  10. GB:29384 RS_2353 P12047 X31045 P12047

  11. Quality Assurance ChemSpider Validation & Standardization Platform http://bit.ly/NZF5VB

  12. http://www.openphacts.org/specs/2013/WD-datadesc-20130912/

  13. Science-Driven Dynamic Integration “What are the physiochemical properties of warfarin salts, tautomers or stereo-isomers?” “What are the biological responses to warfarin?” http://bit.ly/1gzOhS2

  14. Is Anybody Using It?

  15. API Hits (April 2013 – March 2014) 15.8 million total hits

  16. An “App Store”? Explorer Explorer2 ChemBioNavigator Target Dossier Pharmatrek Helium MOE Collector Cytophacts Utopia Garfield SciBite KNIME Mol. Data Sheets PipelinePilotscinav.itTaverna http://www.openphactsfoundation.org/apps.html

  17. Road Map

  18. Version 1.4 API (Coming Soon) • Disease –> Target relationships via DisGeNet • Batch Mode Queries • Performance Improvements

  19. Next Step Priorities • Establish the Open PHACTS foundation • Recruit members and partners • Further develop resources • Open chemical patent data (SureChEMBL) • Further Gene-Disease associations (DisGeNet) • Enhance pathway data • Develop the Open PHACTS VM • Faster data update cycle

  20. Future Data Sources • Bio-assay Ontology queries • Better handling of biotherapeutics • Adverse Event Data • Disease Ontology queries • Integrate Reactome • Integrate IUPHAR • What would you vote for?

  21. Open PHACTS PracticalSemantics Pfizer Limited – Coordinator Universität Wien – Managing entity Technical University of Denmark University of Hamburg, Center for Bioinformatics BioSolveITGmBH Consorci Mar Parc de Salut de Barcelona Leiden University Medical Centre Royal Society of Chemistry VrijeUniversiteit Amsterdam Novartis Merck Serono H. Lundbeck A/S Eli Lilly Netherlands Bioinformatics Centre Swiss Institute of Bioinformatics ConnectedDiscovery EMBL-European Bioinformatics Institute Janssen EsteveAlmirall OpenLinkScibite The Open PHACTS Foundation Spanish National Cancer Research Centre University of Manchester Maastricht University Aqnowledge University of Santiago de Compostela Rheinische Friedrich-Wilhelms-Universität Bonn AstraZeneca GlaxoSmithKline pmu@openphactsfoundation.org@Open_PHACTS

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