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DR. SHABANA ALI (Asso. Prof.)

DR. SHABANA ALI (Asso. Prof.). Kd - Dissociation constant. Drug Dissociation Constant (Kd). Useful measure to describe the strength of binding (or affinity) b/w receptors and their ligands Binding of drug with receptor K 1 [D] +[R] [DR] K -1 Affinity = K 1 /K- 1

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DR. SHABANA ALI (Asso. Prof.)

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  1. DR. SHABANA ALI (Asso. Prof.) Kd- Dissociation constant

  2. Drug Dissociation Constant (Kd) • Useful measure to describe the strength of binding (or affinity) b/w receptors and their ligands Binding of drug with receptor K1 [D] +[R] [DR] K-1 Affinity = K1/K-1 Kd = K-1/K1 cont.

  3. Reversible reaction • At equilibrium, the rate of drug–receptor complex formation [DR] = rate of drug –receptor complex dissociation • K1= rate of formation of drug-receptor complex • K-1= rate of dissociation of drug receptor complex

  4. When binding is in equilibrium= amount of drug bound to receptor is constant Affinity= ratio of k1 and K-1 Kd= the equilibrium dissociation constant & is reciprocal of affinity • The term used to describe the affinity of drugs to receptors • Relationship b/w Kd & affinity is inverse • Smaller the kd greater the affinity

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