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The study investigates how myosin II forces acting on F-actin/FLNA networks can impact FLNA's affinity towards β7-integrin and FilGAP, influencing cell adhesion behavior. Results shed light on cellular mechanotransduction mechanisms.
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Myosin II forces applied to F-actin/FLNA networks change FLNA’s binding affinity to 7-integrin and FilGAP. AJ Ehrlicher et al. Nature000, 1-4 (2011) doi:10.1038/nature10430