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NIH/NIGMS Support of Structural Biology

NIH/NIGMS Support of Structural Biology. NIH individual research grants with crystallography projects (FY 98) primary: 225 grants, $51M total costs secondary: 400 grants, $96M total costs NIGMS is 50% of each

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NIH/NIGMS Support of Structural Biology

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  1. NIH/NIGMS Support of Structural Biology • NIH individual research grants with crystallography projects (FY 98) • primary: 225 grants, $51M total costs • secondary: 400 grants, $96M total costs • NIGMS is 50% of each • NIH program projects and NCRR research resources: approx. $30M for protein crystallography

  2. NIGMS Initiative for Synchrotron Beamlines • Beamline upgrades for benefit of general users • Reports on increasing demand for user access and beamline needs • Estimate of doubling of capacity for crystallographic experiments from staff increases and equipment upgrades • Letter to synchrotron facility directors inviting informal proposals • NIGMS synchrotron advisory group • FY99 funding of $7M from NIGMS

  3. Synchrotron Beamline Upgrades Supported by NIGMS Stanford Synchrotron Research Laboratory • upgrades to 4 beamlines • CCD detectors • computer • wet lab • four beamline scientists/technicians • one staff for new review/scheduling process • $1,770K equipment • $705K annual – staff

  4. Synchrotron Beamline Upgrades Supported by NIGMS National Synchrotron Light Source • reconstruction of bending magnet beamline • ncluding beamline optics, monochrometer, detector, crystallography station • four beamline scientists/technicians • $2,372K equipment/construction • $670K annual – staff

  5. Synchrotron Beamline Upgrades Supported by NIGMS Cornell High Energy Synchrotron Source • upgrades to three beamlines • beamline optics and cooling equipment, monochrometer, automation/ monitors, computer • two beamline scientists • $1,238K equipment • $340K annual – staff

  6. Synchrotron Beamline Upgrades Supported by NIGMS Advanced Light Source • upgrade to the focusing optics for one beamline and a detector • low temperature system and computer for a new beamline • four beamline scientists/ technicians • $963K equipment • $259K annual – staff

  7. Synchrotron Beamline Construction Supported by NIGMS Center for Advanced Microstructures and Devices • construction of a new crystallographic beamline • two beamline scientists • cofunded with the NSF, Louisiana State University, and a consortium of PIs in the southern U.S. • $1,260K construction/equipment (NIGMS & NSF) • $206K annual – staff (NIGMS & NSF)

  8. Synchrotron Beamline Construction Supported by NIGMS Advanced Photon Source • development of a new crystallographic sector of two crystallographic beamlines • partnership with the NCI • two years of NIGMS/NCI funding for construction. • $18M construction/equipment (NIGMS & NCI)

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