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Simon Jordan 1 ,  Peter Goldstraw 1 ,  Elizabeth Belcher 1 ,  Ambrus Szántó 1 ,

Prognostic Factors For Long-term Survival After Pulmonary Metastasectomy In Sarcoma Patients: A 12 year experience. Simon Jordan 1 ,  Peter Goldstraw 1 ,  Elizabeth Belcher 1 ,  Ambrus Szántó 1 , Jeremy Whelan 2 ,  Beatrice Seddon 2 ,  Maria Michelagnoli 2 ,

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Simon Jordan 1 ,  Peter Goldstraw 1 ,  Elizabeth Belcher 1 ,  Ambrus Szántó 1 ,

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  1. Prognostic Factors For Long-term Survival After Pulmonary Metastasectomy In Sarcoma Patients: A 12 year experience Simon Jordan1,  Peter Goldstraw1,  Elizabeth Belcher1,  Ambrus Szántó1, Jeremy Whelan2,  Beatrice Seddon2,  Maria Michelagnoli2, Anna Cassoni2,  Sandra Strauss2,  Michelle Scurr3,  Frank Saran3, Ian Judson3,  George Ladas1 1Royal Brompton Hospital,London,United Kingdom; 2University College Hospital,London,United Kingdom; 3Royal Marsden Hospital,London,United Kingdom

  2. Background • Pulmonary metastasectomy is an established treatment modality in selected patients • Often the lung is the only site of recurrence • Prognostic factors associated with individual cell types have not been intensively studied

  3. Aims • To evaluate the long-term survival of patients undergoing pulmonary metastasectomy for sarcoma • To identify factors affecting outcome • To investigate the prognostic significance of pre-operative pleural effusion

  4. Methods • A retrospective review of patients who underwent surgery by between 1995 and 2007 • We examined the impact of age, gender, sarcoma type, disease-free interval (DFI), number and distribution of metastases, prior metastasectomy and the presence of a pleural effusion on survival • Actuarial survival was estimated using Kaplan-Meier methods and comparisons by Cox regression

  5. Patients demographics

  6. Overall survival

  7. Survival according to DFI

  8. Survival according to repeat metastasectomy

  9. Multivariate Analysis Univariate Analysis

  10. Survival according to sarcoma subtype

  11. Survival according to Number of Metastases

  12. Conclusions • Resection of sarcomatous pulmonary metastases confers good long-term survival, with low operative mortality • Patients with a DFI of 12 months or longer have a significantly better prognosis • Repeat metastasectomy in selected patients is associated with a good prognosis • The presence of a pleural effusion is not a negative prognostic factor and therefore should not preclude surgery

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