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Immunogenetics chapter 22 select topics pp. 611-620

Immunogenetics chapter 22 select topics pp. 611-620. Topic Outline. Overview of the Immune System 1 st and 2 nd lines of Defense The Immune System B cells The antibody & antibody diversity Vaccinations Breast Feeding Diagnostic applications T cells Allergies.

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Immunogenetics chapter 22 select topics pp. 611-620

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  1. Immunogeneticschapter 22select topicspp. 611-620

  2. Topic Outline • Overview of the Immune System • 1st and 2nd lines of Defense • The Immune System • B cells • The antibody & antibody diversity • Vaccinations • Breast Feeding • Diagnostic applications • T cells • Allergies

  3. Immune System and Lymphoid Tissue

  4. Let’s take a look at the different types of Leukocytes

  5. Monocyte Neutrophil Eosinophil Basophil Dendritic Cell Lymphocyte

  6. EXAMPLES FIRST LINE OF DEFENSE Can by physical and chemical Mucosal lining of GI Epidermis Ciliated epithelium of respiratory tract

  7. Second line of defense include the following processes: • Phagocytosis • Complement • Interferons • Inflammation • Pyrogens

  8. Phagocytosis

  9. Complement Cascade

  10. 3rd line of defense“The Immune System”

  11. Summary Lines of Defense INNATE ACQUIRED

  12. Immune System B cells T cells

  13. Lymph nodes are contain high concentrations lymphocytes

  14. Let’s look more closely at the B lymphocytes

  15. B Cell: humoral or antibody mediated immunityANTIBODIES=IMMUNOGLOBULINS • Humoral Immunity • Matures in bone marrow • Moves to lymph nodes (& other locations) • Secretes antibodies “as plasma cell” • Also creates “memory” B cells B-lymphocyte

  16. CLONAL SELECTION

  17. Different classes of immunoglobulins or antibodies IgA IgM IgG IgE IgD

  18. Antibody Diversity • How do we acquire so many different types of antibodies? • Somatic recombination • Junctional diversity • hypermutations

  19. V J C Antibody genes are composed of segments

  20. Somatic Recombination • http://www.bio.davidson.edu/courses/Immunology/Flash/somaticrecomb.html

  21. How are vaccinations related to immunity? Active and Passive

  22. Active Vaccinations: AntibodyProduction Memory Cells!

  23. Onto T Cells The next part gets tricky

  24. All T cells require cell to cell contact

  25. CD8+ CD4+ http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter24/animation__cytotoxic_t-cell_activity_against_target_cells__quiz_2_.html

  26. T Cells These are some of the General characteristics of the T Cell receptor for antigen recognition. VJC (D) + D in the beta chain

  27. Cytotoxic T Cell and MHC I Antigen presentation CD8+ cell

  28. Cytotoxic T cell= CD8+

  29. Cytotoxic T cell= CD8+

  30. Tissue Transplantation • MHC proteins differ between individuals

  31. The major histocompatibility complex • is a large group of genes on chromosome 6

  32. Helper T Cell and MHC II Antigen presentation

  33. B lymphocytes source of antibodies Overview of T lymphocytes

  34. Cancer cell being attacked by cytotoxic T cells After release of perforin

  35. Allergic Response I.

  36. AllergiesB cell also directly stimulated IgE

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