Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets)

1. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex (Generic Exemestane Tablets) is used to treat hormone dependent early breast cancer in postmenopausal women after they have completed 2 to 3 years of treatment with the medicine Tamoxifen. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Active Ingredient The active ingredient contained in Aromex tablets is The active ingredient contained in Aromex tablets is Exemestane. Each 25 mg Aromex tablet contains 25 Exemestane. Each 25 mg Aromex tablet contains 25 mg of Exemestane. mg of Exemestane. The inactive ingredients present in Aromex tablets are mannitol, crospovidone, polysorbate 80, hypromellose, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, simethicone, polyethylene glycol 6000, sucrose, magnesium carbonate, titanium dioxide, methylparaben, and polyvinyl alcohol. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Chemical Structure The structure of Exemestane is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex tablets are manufactured by Alpha-Pharma Healthcare Private limited, India in the strength of 25 mg. (Website: www.alpha-pharma.com www.alpha-pharma.com) URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Exemestane Tablets – Brand Names Exemestane tablets are available under various Drug trade names that include Aromasin,Aromex, Exeget, X -Cel FC and Xtane. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Uses of Aromex Tablets Aromex (Generic Exemestane Tablets) is used to treat early and advanced breast cancer in women who have already stopped menstruating (postmenopausal). Many breast cancer tumors grow in response to estrogen. Exemestane interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, which will limit the growth of the tumor. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Uses of Aromex Tablets Exemestane tablets are indicated for adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of Tamoxifen and are switched to Exemestane tablets for completion of a total of five consecutive years of adjuvant hormonal therapy. Exemestane tablets are indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following Tamoxifen therapy. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets Dosage The dosage of Aromex tablets Aromex tablets (Generic Exemestane Tablets) for the following indications 1)Adjuvant treatment of postmenopausal women with estrogen- receptor positive early breast cancer who have received two to three years of Tamoxifen and are switched to Exemestane tablets for completion of a total of five consecutive years of adjuvant hormonal therapy. 2)The treatment of advanced breast cancer in postmenopausal women whose disease has progressed following Tamoxifen therapy. is given below: URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets Dosage The dosage of Aromex tablets Aromex tablets (Generic Exemestane Tablets) is given below: The recommended dose of Aromex (Generic Exemestane tablets) in early and advanced breast cancer is one 25 mg tablet once daily after a meal. Your doctor will tell you how to take Aromex and for how long. At a single dose of 25 mg given after a meal, average peak plasma levels of 18 ng/mL are achieved within 2 hours post-dosing. Food was shown to enhance absorption. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets Contraindications Aromex tablets are contraindicated in patients with a hypersensitivity to Exemestane or any of the other ingredients of this medicine. They are also contraindicated in in pregnant or lactating women or women of premenopausal endocrine status. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Storage Instructions Aromex (Generic Exemestane Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Warnings Reductions in bone mineral density (BMD) over time are seen with Exemestane use. Routine checking of your vitamin D level will also be made before treatment, as your level could be very low in the early stages of breast cancer. You will be given vitamin D supplement if your levels are below normal. Exemestane tablets should not be coadministered with estrogen- containing agents as these could interfere with its pharmacologic action. In patients with early breast cancer, the incidence of hematological abnormalities of Common Toxicity Criteria (CTC) grade 1 or greater was lower in the Exemestane treatment group, compared with Tamoxifen. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Warnings Before starting treatment with Aromex, your doctor may want to take blood samples to confirm you have reached the menopause. Exemestane tablets are not indicated for the treatment of breast cancer in premenopausal women. Before taking Aromex, inform your doctor if you have problems with your liver or kidneys. Inform your doctor if you have a history or are suffering from any condition which affects the strength of your bones. Your doctor may want to measure your bone density before and during the treatment of Generic Exemestane. This is because medicines of this class lower the levels of female hormones and this may lead to a loss of the mineral content of bones, which might decrease their strength. Embryo-Fetal Toxicity: Based on findings from animal studies and its mechanism of action, exemestane can cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets and Alcohol The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Exemestane. If you experience hot flashes or sweating while taking this medicine, avoid alcohol, smoking and drinks with caffeine. This may help to decrease these side effects. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Side Effects In the adjuvant treatment of early breast cancer, the most common side effects occurring in 10% or more of patients in any treatment group (Exemestane Vs. Tamoxifen) were mild to moderate hot flushes (21.2% vs. 19.9%), fatigue (16.1% vs. 14.7%), arthralgia (14.6% vs. 8.6%), headache (13.1% vs. 10.8%), insomnia (12.4% vs. 8.9%), and increased sweating (11.8% vs. 10.4%). Discontinuation rates due to AEs were similar between Exemestane and Tamoxifen (6.3% vs. 5.1%). Incidences of cardiac ischemic events (myocardial infarction, angina, and myocardial ischemia) were Exemestane 1.6%, Tamoxifen 0.6%. Incidence of cardiac failure: Exemestane 0.4%, Tamoxifen 0.3%. In the treatment of advanced breast cancer, the most common side effects were mild to moderate and included hot flushes (13% vs. 5%), nausea (9% vs. 5%), fatigue (8% vs. 10%), increased sweating (4% vs. 8%), and increased appetite (3% vs. 6%) for Exemestane and Megestrol Acetate, respectively. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Side Effects The side effects of all grades and causes occurring in 5% or more of advanced breast cancer patients reported during IES study include Visual disturbances, Nausea, Fatigue, Arthralgia, Pain in limb, Back pain, Osteoarthritis, Headache, Dizziness,Insomnia, Depression, Increased sweating, Hot flushes and Hypertension. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets Overdose During clinical trials Exemestane (Aromex tablets) has been administered as a single dose to healthy female volunteers at doses as high as 800 mg and postmenopausal women with advanced breast cancer have been administered doses as high as 600 mg daily for 12 weeks. These dosages were well tolerated. There is no specific antidote to overdosage and treatment should be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is recommended. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets During Pregnancy Exemestane (Aromex tablets) has been classified by the US FDA as Pregnancy Category X. Exemestane is contraindicated in pregnant women and only indicated in postmenopausal women. Do not take Generic Exemestane if you are pregnant or breast-feeding. Based on findings in animal studies and its mechanism of action, Exemestane can cause fetal harm when administered to a pregnant woman. Limited human data from case reports are insufficient to inform a drug-associated risk. In animal reproduction studies, administration of Exemestane to pregnant rats and rabbits caused increased incidence of abortions, embryo-fetal toxicity, and prolonged gestation with abnormal or difficult labor. Advise pregnant women of the potential risk to a fetus. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets During Nursing There is no information on the presence of Exemestane (Aromex tablets) in human milk, or on its effects on the breast fed infant or milk production. Exemestane is present in rat milk at concentrations similar to maternal plasma. Because of the potential for serious adverse reactions in breast-fed infants from Aromex tablets, advise a woman not to breastfeed during treatment with Aromex tablets and for 1 month after the final dose. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

21. Aromex Tablets by Alpha Pharma (Generic Exemestane Tablets) Aromex Tablets Aromex Tablets (Generic Exemestane Tablets) by Alpha-Pharma Healthcare Private limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-aromasin-aromex-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )