Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets)

1. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupron XL tablets (Generic Bupropion Hydrochloride XL tablets ) are used for the treatment of Major Depressive Disorder (MDD). The efficacy of the sustained-release formulation of Bupropion HCl in the maintenance treatment of MDD was established in a long-term (up to 44 weeks), placebo-controlled trial in patients who had responded to Bupropion in an 8-week study of acute treatment. Bupropion Hydrochloride Extended-Release tablets (XL) are also used for the prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD). The efficacy of Bupropion hydrochloride extended-release tablets in the prevention of seasonal major depressive episodes was established in 3 placebo-controlled trials in adult outpatients with a history of MDD. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Active Ingredient The active ingredient present in Bupron XL tablets is Bupropion Hydrochloride. Each prolonged release film coated bi-layer tablet contains 150 mg or 300 mg of Bupropion Hydrochloride. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Chemical Structure The structure of Bupropion Hydrochloride is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupron XL Tablets are manufactured by Sun Pharmaceutical Industries Limited, India in the strengths of 150 mg and 300 mg. (Website: https://sunpharma.com/ https://sunpharma.com/ ) URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupropion Hydrochloride Tablets – Brand Names Bupropion Hydrochloride tablets are available under various Drug trade names that include Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage, Bupron, Bupron XL, Bupron SR, Nicotex, Nicotex SR, Smoquit -SR, Aplenzin, Budeprion SR, Buproban, Forfivo XL, Bupdep, Bupep SR, Bupep SR 150, Ession ER 150 and Bupisure. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Uses of Bupron XL Tablets Bupron XL Tablets (Generic Bupropion Hydrochloride XL tablets ) is used to treat depression. It may also be used to prevent seasonal affective disorder (SAD), a type of depression that occurs each year at the same time (for example, during winter). This medication can improve your mood and feelings of well-being. It may work by restoring the balance of certain natural substances (dopamine, norepinephrine) in the brain. It is also used as part of a support program to help people stop smoking. The efficacy of Bupropion Hydrochloride as a treatment for major depressive disorder was established with the immediate-release formulation of Bupropion in two 4-week, placebo-controlled trials in adult inpatients and in one 6-week, placebo-controlled trial in adult outpatients. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Uses of Bupron XL Tablets The efficacy of Bupropion Hydrochloride XL for the prevention of seasonal major depressive episodes associated with seasonal affective disorder was established in 3 double-blind, placebo-controlled trials in adult outpatients with a history of major depressive disorder with an autumn-winter seasonal pattern (as defined by DSM-IV criteria). Treatment was initiated prior to the onset of symptoms in the autumn (September to November) and was discontinued following a 2 week taper that began the first week of spring (fourth week of March), resulting in a treatment duration of approximately 4 to 6 months for the majority of patients. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupron XL Tablets Dosage The dosage of Bupron XL tablets (Bupropion Hydrochloride XL tablets) is given below: Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage should be increased gradually to reduce seizure risk. Periodically reassess the dose and need for maintenance treatment. The recommended dosage of Generic Bupropion XL (Bupron XL Tablets) is given below. Major Depressive Disorder: The starting dose is 150 mg once daily. The usual target dose: 300 mg once daily. After 4 days, the dose may increased to 300 mg once daily. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupron XL Tablets Dosage The dosage of Bupron XL tablets (Bupropion Hydrochloride XL tablets) is given below: Seasonal Affective Disorder: Begin treatment in the autumn prior to onset of seasonal depressive symptoms. Starting dose: 150 mg once daily. Usual target dose: 300 mg once daily. After one week, the dose may be increased to 300 mg once daily. Continue treatment through the winter season. Hepatic Impairment: Moderate to severe hepatic impairment: 150 mg every other day Mild hepatic impairment: Consider reducing the dose and/or frequency of dosing. Renal Impairment: Consider reducing the dose and/or frequency of dosing. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Contraindications Bupron XL tablets are contraindicated in persons with a hypersensitivity (allergy) to Bupropion Hydrochloride or any of the other ingredients of this medicine. They are also contraindicated in patients with seizure disorder or with a current or prior diagnosis of bulimia or anorexia nervosa as a higher incidence of seizures was observed in such patients treated with Bupropion Hydrochloride extended-release tablets (XL). Bupropion hydrochloride extended-release tablets (XL) are contraindicated in patients undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Contraindications The use of MAOIs (intended to treat psychiatric disorders) concomitantly with Bupron XL or within 14 days of discontinuing treatment with Bupropion Hydrochloride extended-release tablets (XL) is contraindicated. There is an increased risk of hypertensive reactions when Bupron XL are used concomitantly with MAOIs. The use of Bupropion Hydrochloride extended-release tablets (XL) within 14 days of discontinuing treatment with an MAOI is also contraindicated. Starting Bupron XL in a patient treated with reversible MAOIs such as linezolid or intravenous methylene blue is contraindicated. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Storage Instructions Bupron XL tablets (Generic Bupropion Hydrochloride XL tablets ) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Warnings Suicidal Thoughts and Behaviors in Children, Adolescents, and Young Adults: Patients with Major Depressive Disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Neuropsychiatric Adverse Events and Suicide Risk in Smoking Cessation Treatment: Bupropion Hydrochloride extended-release tablets (XL) are not approved for smoking cessation treatment; however, Bupropion HCl sustained-release is approved for this use. Serious neuropsychiatric adverse events have been reported in patients taking Bupropion for smoking cessation. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Warnings Seizure: Bupron XL tablets can cause seizure. The risk of seizure is dose- related. The dose should not exceed 300 mg once daily. Increase the dose gradually. Discontinue Generic Bupropion Hydrochloride Extended- Release tablets (XL) and do not restart treatment in case the patient experiences a seizure. Hypertension: Treatment with Generic Bupropion Hydrochloride Extended-Release tablets (XL) can result in elevated blood pressure and hypertension. Assess blood pressure before initiating treatment with Bupron XL tablets, and monitor periodically during treatment. Activation of Mania/Hypomania: Antidepressant treatment can precipitate a manic, mixed, or hypomanic manic episode. The risk appears to be higher in patients with bipolar disorder or who have risk factors for bipolar disorder. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Warnings Psychosis and Other Neuropsychiatric Reactions: Depressed patients treated with Bupropion Hydrochloride have had a variety of neuropsychiatric signs and symptoms, including delusions, hallucinations, psychosis, concentration disturbance, paranoia, and confusion. Angle-Closure Glaucoma: The pupillary dilation that occurs following use of many antidepressant drugs including Bupropion Hydrochloride extended-release tablets (XL) may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Side Effects Bupropion Hydrochloride Side effects with an incidence rate of 5% or more include dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, rash. Tell your doctor right away in case you have any serious side effects, including: fast/pounding/irregular heartbeat, mental/mood changes (such as anxiety, agitation, confusion, unusual behavior/thinking, memory loss), unusual weight loss or gain. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Side Effects Stop taking Bupron XL tablets and get medical help immediately if you have any very serious side effects, including: seizure, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), painful sores in the mouth/around the eyes, severe dizziness, trouble breathing. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Overdose Overdoses of up to 30 grams or more of Bupropion Hydrochloride (Bupron XL tablets) have been reported. Seizure was reported in approximately one-third of all cases, but patients generally recovered without significant sequelae. However, when multiple medications are involved in overdose, the other medications may increase the risk of more serious complications. Other serious reactions reported with overdoses of Bupropion alone included hallucinations, loss of consciousness, sinus tachycardia, and ECG changes such as conduction disturbances (including QRS prolongation) or arrhythmias. Fever, muscle rigidity, rhabdomyolysis, hypotension, stupor, coma, and respiratory failure have been reported mainly when bupropion was part of multiple drug overdoses. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Overdose Any suspected overdose should be treated as an emergency. The person should be taken to the emergency department for observation and treatment. The prescription bottle of medication (and any other medication suspected in the overdose) should be brought as well, because the information on the prescription label can be helpful to the treating physician in determining the number of pills ingested. There are no known antidotes for Bupropion HCl. In case of an overdose, provide supportive care, including close medical supervision and monitoring. Consider the possibility of multiple drug overdose. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Induction of emesis is not recommended. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

21. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) Bupron XL Tablets During Pregnancy Bupropion Hydrochloride (Bupron XL tablets) has been classified by the US FDA as Pregnancy Category C. Data from epidemiological studies including pregnant women exposed to Bupropion in the first trimester indicate no increased risk of congenital malformations overall. No clear evidence of teratogenic activity was found in reproductive developmental studies conducted in rats and rabbits. However, in rabbits, slightly increased incidences of fetal malformations and skeletal variations were observed at doses approximately equal to the maximum recommended human dose (MRHD) and greater and decreased fetal weights were seen at doses twice the MRHD and greater. This medicine should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Neonates exposed to this drug late in the third trimester may require respiratory support, tube feeding, and/or prolonged hospitalization. Exposed neonates should be monitored after delivery for direct toxic effects of this medicine. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

22. Bupron XL Tablets (Generic Bupropion Hydrochloride XL Tablets) For more details on Bupron XL Tablets click here Bupron XL Tablets (Bupropion Bupropion Hydrochloride XL Tablets) by Sun Pharmaceutical Industries Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html https://www.clearskypharmacy.biz/generic-wellbutrin-xl-bupron-xl-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )