Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets)

1. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas (Generic Clopidogrel Bisulfate Tablets) is a platelet inhibitor and prevent blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It used to treat patients with Acute coronary syndrome (unstable angina (UA)/non-ST-segment elevation ACS (NSTEMI)& ST-elevation myocardial infarction (STEMI) ), recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Acute coronary syndrome: Acute coronary syndrome: In case of patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)] including patients who are to be managed medically and those who are to be managed with coronary revascularization, Clopivas has been observed to decrease the rate of a combined endpoint of cardiovascular death, myocardial infarction (MI), or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia. In case of patients with ST-elevation myocardial infarction (STEMI), Clopidogrel tablets have been observed to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction, or stroke. The benefit for patients who undergo primary PCI is unknown. Recent myocardial infarction (MI), recent stroke, or established peripheral Recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease: arterial disease: Clopivas (Clopidogrel Bisulfate tablets) has been observed to reduce the combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Active Ingredient The active ingredient contained in Clopivas tablets is Clopidogrel Bisulfate. Each film-coated Clopivas tablet contains 75 mg or 300 mg of Clopidogrel Bisulfate. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Chemical Structure The structure of Clopidogrel Bisulfate is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets are manufactured by Cipla limited, India in the strength of 75 mg and 300 mg. (Website: www.cipla.com) URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopidogrel Bisulfate Tablets – Brand Names Clopidogrel Bisulfate is available under various drug trade names that include Plavix, Clopivas, Ceruvin, Clavix, Clopilet, Deplatt and Plagril. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Uses of Clopivas Tablets Clopivas (Generic Clopidogrel Bisulfate Tablets) is used alone or together with aspirin to lessen the chance of a heart attack or stroke. It is given to patients with acute coronary syndrome (ACS), to patients who have already had a heart attack, severe chest pain, or a stroke, or to patients with other circulation problems (eg, peripheral arterial disease) that could cause a stroke or heart attack. Acute coronary syndrome is a condition where the blood flow to the heart is blocked. A heart attack or stroke may occur when a blood vessel is blocked by a blood clot. Clopidogrel is a platelet inhibitor. It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidogrel may also increase the chance of serious bleeding in some people. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Dosage The dosage of Clopivas tablets Clopivas tablets (Generic Clopidogrel Bisulfate Tablets) is given below: Acute Coronary Syndrome: Acute Coronary Syndrome: Clopivas tablets can be administered with or without food. For patients with non-ST-elevation ACS (UA/NSTEMI), initiate with a single oral loading dose of Clopivas 300 mg and then continue at Clopivas 75 mg once daily. Initiate Aspirin (75 to 325 mg once daily) and continue in combination with Clopivas tablets. For patients with STEMI, the recommended dose is Clopivas 75 mg once daily orally, administered in combination with Aspirin (75 to 325 mg once daily), with or without thrombolytics. Clopivas may be initiated with or without a loading dose. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Dosage Clopivas tablets (Generic Clopidogrel Bisulfate Tablets) is given below: Recent MI, Recent Stroke or Established PAD: Recent MI, Recent Stroke or Established PAD: The recommended dose is Clopivas 75 mg once daily orally, with or without food. The dosage of Clopivas tablets URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Contraindications Clopivas tablets are contraindicated in patients with a hypersensitivity to Clopidogrel Bisulfate or any other component of this medication. Clopivas is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage. Clopivas is also contraindicated in patients with severe liver impairment. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Storage Instructions Clopivas (Generic Clopidogrel Bisulfate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Warnings The annual incidence of hemorrhage may be increased by the administration of Aspirin along with Clopivas tablets. Hence patients must not use aspirin when undergoing Clopivas therapy. Use of non-steroidal anti-inflammatory drugs is discouraged in patients taking Clopidogrel due to increased risk of digestive tract hemorrhage. The other precautions are CYP2C19 inhibitors: Avoid concomitant use of Omeprazole or Esomeprazole. Bleeding: Clopivas (Generic Clopidogrel Bisulfate Tablets) increases risk of bleeding. Discontinuation: Premature discontinuation increases risk of cardiovascular events. Discontinue 5 days prior to elective surgery that has a major risk of bleeding. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Warnings Thrombotic thrombocytopenic purpura (TTP) has been reported. Cross-reactivity among thienopyridines has been reported. Thienopyridines, including Clopidogrel (Clopivas tablets), increase the risk of bleeding. In case a patient has to undergo surgery and an antiplatelet effect is not desired, discontinue Clopivas (Clopidogrel Bisulfate Tablets) five days prior to surgery that has a major risk of bleeding. In cases of confirmed isolated activated partial thromboplastin time (aPTT) prolongation with or without bleeding, acquired hemophilia should be considered. Hypersensitivity, including rash, angioedema or hematologic reaction, has been reported in patients receiving Clopidogrel Bisulfate (Clopivas tablets), including patients with a history of hypersensitivity or hematologic reaction to other thienopyridines. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets and Alcohol The main side effect of Clopidogrel (Clopivas tablets) is bleeding more easily than normal. You may have nosebleeds, heavier periods, bleeding gums or bruising. You can drink alcohol with Clopidogrel. But do not drink too much while taking Clopivas tablets. Alcohol doesn't affect Clopidogrel itself, but just be aware that drinking alcohol can irritate your stomach lining. This could increase the risk of getting a bleeding in the stomach. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Side Effects Bleeding, including life-threatening and fatal bleeding, is the most commonly reported Clopidogrel Bisulfate (Clopivas tablets) side effect. Another serious side effect is Thrombotic thrombocytopenic purpura. Some other side effects that were reported include thrombocytopenia, leucopenia, neutropenia (including severe neutropenia), granulocytopenia, anemia, cross-reactive drug hypersensitivity among thienopyridines (such as ticlopidine, prasugrel), paresthesia, dizziness, vertigo, abdominal pain, dyspepsia, gastritis, vomiting, nausea, constipation, flatulence, gynecomastia, glomerulonephritis, hematuria. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Overdose Platelet inhibition by Clopidogrel Bisulfate (Clopivas tablets) is irreversible and will last for the life of the platelet. Overdose following Clopidogrel administration can result in bleeding complications. A single oral dose of Clopidogrel at 1,500 or 2,000 mg/kg was lethal to mice and to rats and at 3,000 mg/kg to baboons. Symptoms of acute toxicity observed in animals were vomiting, prostration, difficult breathing, and gastrointestinal hemorrhage. Based on biological plausibility, platelet transfusion may restore clotting ability. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets During Pregnancy Clopidogrel Bisulfate (Clopivas tablets) has been classified by the US FDA as Pregnancy Category B. Reproduction studies performed in rats and rabbits at doses up to 500 and 300 mg/kg/day, respectively (65 and 78 times the recommended daily human dose, respectively, on a mg/m2 basis), revealed no evidence of impaired fertility or fetotoxicity due to Clopidogrel Bisulfate. There are, however, no adequate and well-controlled studies with clopidogrel in pregnant women. Because animal reproduction studies are not always predictive of a human response, Clopivas (Generic Clopidogrel Bisulfate Tablets) should be used during pregnancy only if clearly needed. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets During Nursing Studies in rats have shown that Clopidogrel (Clopivas tablets) and/or its metabolites are excreted in the milk. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Clopidogrel, a decision should be made whether to discontinue nursing or to discontinue the Clopivas tablets, taking into account the importance of the medicine to the mother. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Clopivas Tablets by Cipla (Generic Clopidogrel Bisulfate Tablets) Clopivas Tablets Clopivas Tablets (Generic Clopidogrel Bisulfate Tablets) by Cipla Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html https://www.clearskypharmacy.biz/generic-plavix-clopivas-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )