Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray)

1. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) is indicated for the treatment of nasal symptoms of seasonal or perennial allergic rhinitis unresponsive to conventional therapy in adults and children six years of age and older. Derinide AQ Nasal Spray is also used for the treatment of nasal polyps and in the prevention of nasal polyps after polypectomy in patients 12 years and older. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Active Ingredient The active ingredient contained in Derinide AQ Nasal Spray is Budesonide. Each actuation delivers 64 mcg of Budesonide. Each canister contains 200 metered doses. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Chemical Structure The structure of Budesonide is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray is manufactured in the strength of 64 mcg by Zydus Healthcare Limited, India and marketed by German Remedies Limited, India. (Website: https://www.zydushealthcare.com/ https://www.zydushealthcare.com/ ) URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Budesonide Nasal Spray – Brand Names Budesonide Nasal Spray is available as Rhinocort, Derinide AQ, Budenase, Rhinosol, Pulmicort, Budicort, Symbicort, and Noex. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Uses of Derinide AQ 64 mcg Nasal Spray Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) is used for the treatment of symptoms of seasonal or perennial allergic rhinitis (such as stuffy/runny nose, itchy eyes/nose/throat, sneezing) due to allergies and asthma in adults and children 6 years and above. Budesonide belongs to a class of drugs known as corticosteroids. It works by reducing swelling (inflammation) in the nasal passages. Derinide AQ Nasal Spray is also used for the treatment of nasal polyps. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Dosage The dosage of Derinide AQ Nasal Spray Derinide AQ Nasal Spray (Budesonide Nasal Spray) for adults including the elderly and Children Over 12 Years for treatment of Rhinitis is given below: Initial Dose: The recommended starting dose is 4 sprays per day (total daily dose of 256 mcg). The dose can be administered as 2 sprays in each nostril once daily in the morning or divided into two administrations daily of 1 spray in each nostril in the morning and evening. Maintenance Dose: After the desired clinical effect is obtained and symptoms are controlled, the maintenance dose should be reduced to the smallest amount necessary to control the symptoms. The dose can be reduced to 1 spray per nostril once daily in the morning (total daily dose of 128 mcg) URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Dosage The dosage of Derinide AQ Nasal Spray (Budesonide Nasal Spray) for Children (6 Years to Less Than 12 Years of Age) for treatment of Rhinitis is given below: Initial Dose: The recommended dose is 1 spray in each nostril (total dose 128 mcg) once daily in the morning. If symptoms do not improve, the dose can be increased up to 2 sprays per nostril (up to 256 mcg total daily dose) once daily in the morning. Maintenance Dose: Once allergy symptoms improve, the maintenance dose should be reduced to 1 spray in each nostril once daily in the morning. Parents should talk to their child’s physician if the child needs to use the spray for longer than two months a year. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Dosage The dosage of Derinide AQ Nasal Spray (Budesonide Nasal Spray) for Adults and Children (12 Years of Age and Older) for treatment or prevention of Nasal Polyps is given below: The recommended dose is 1 spray into each nostril morning and evening (total daily dose of 256 mcg). URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Contraindications Derinide AQ Nasal Spray is contraindicated in patients with a hypersensitivity to Budesonide or any other component of this medication. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Storage Instructions Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Warnings Local Nasal Effects: Epistaxis, Candida albicans infections, nasal septal perforation, impaired wound healing. Monitor patients periodically for signs of adverse effects on the nasal mucosa. Avoid use in patients with recent nasal ulcers, nasal surgery, or nasal trauma. Epistaxis: In clinical studies of 3 to 52 weeks’ duration epistaxis was observed more frequently in patients treated with Budesonide Nasal Spray than those who received placebo. Candida Infection: During clinical studies with Budesonide administered intranasally, the development of localized infections of the nose and pharynx with Candida albicans has occurred. When such an infection develops, it may require treatment with appropriate local or systemic therapy and discontinuation of treatment with Derinide AQ Nasal Spray. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Warnings Nasal Septal Perforation: Instances of nasal septum perforation have been reported following the intranasal application of corticosteroids, including Budesonide. Impaired Wound Healing: Due to the inhibitory effect of corticosteroids on wound healing, patients who have experienced recent nasal septal ulcers, nasal surgery, or nasal trauma should not use a nasal corticosteroid until healing has occurred. Hypersensitivity Reactions Including Anaphylaxis: Hypersensitivity reactions including anaphylactic reaction, urticaria, rash, dermatitis, angioedema and pruritus may occur. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Warnings Immunosuppression: Patients who are on drugs that suppress the immune system are more susceptible to infections than healthy individuals. Potential worsening of infections (e.g., existing tuberculosis, fungal bacterial, viral, or parasitic infections; or ocular herpes simplex). Use with caution in patients with these infections. Hypercorticism and adrenal suppression: May occur with very high dosages or at the regular dose in susceptible individuals. If such changes occur, reduce treatment with Derinide AQ Nasal Spray slowly. Effect on growth: Monitor growth of pediatric patients. Glaucoma and cataracts: Close monitoring is warranted. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Side Effects During clinical trials with patients 6 years and above the reported Budesonide Nasal Spray (Derinide AQ Nasal Spray) side effects which occurred at a frequency of 2% or more were: epistaxis, pharyngitis, bronchospasm, coughing and nasal irritation. Systemic and intranasal corticosteroids use can result in the following: Epistaxis, Candida albicans infection, nasal septum perforation, and impaired wound healing, Hypersensitivity Including Anaphylaxis, Immunosuppression, Hypercorticism and Adrenal Suppression, Growth Effect, Glaucoma and Cataracts. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Overdose Inhalation of high doses of corticosteroids including Derinide AQ (Budesonide Nasal Spray) may lead to suppression of the hypothalamic-pituitary-adrenal (HPA) axis function. No special emergency action is required to be taken. Treatment with Budecort Nasal Spray should be continued at the recommended dose to control the symptoms. Acute overdosage with this dosage form is unlikely since one 200 spray bottle of Derinide AQ Nasal Spray 64 mcg only contains approximately 12.8 mg of budesonide. Chronic overdosage may result in signs/symptoms of hypercorticism. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Overdose When Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) is used chronically in excessive doses or in conjunction with other corticosteroid formulations, systemic corticosteroid effects such as hypercorticism and adrenal suppression may appear. If such changes recur, the dosage of Derinide AQ Nasal Spray (Budesonide) should be discontinued slowly consistent with accepted procedures for discontinuation of chronic steroid therapy. The restoration of the hypothalamic-pituitary-axis may be a slow process and during periods with pronounced physical stress such as severe infections, trauma, and surgical operations, a supplement with systemic steroids may be advisable. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray During Pregnancy Budesonide (Derinide AQ Nasal Spray) has been classified by the US FDA as Pregnancy Category B. Results from Clinical studies and from worldwide post marketing experience indicate no increased risk for overall congenital malformations from the use of inhaled or intranasal Budesonide during early pregnancy. As with other medicines the administration of Budesonide Nasal Spray during pregnancy requires that the benefits for the mother are weighed against the risk for the foetus. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) Derinide AQ Nasal Spray Derinide AQ Nasal Spray (Generic Budesonide Nasal Spray) is manufactured by Zydus Healthcare Limited, India and marketed by German Remedies Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html https://www.clearskypharmacy.biz/generic-rhinocort-derinide-aq-by-german-remedies.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )