Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets)

1. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine (Generic Minocycline Hydrochloride Tablets) is used to treat the following infections due to susceptible microorganisms: acne, gonorrhoea, non-gonococcal urethritis, syphilis, prostatitis, acute and chronic bronchitis, bronchiectasis, lung abscess, pneumonia, ear, nose and throat infections, urinary tract infections, pelvic inflammatory disease, skin and soft tissue infections, ophthalmological infections, nocardiosis, prophylactic treatment of asymptomatic meningococcal carriers, pre- and post-operative prophylaxis of infection, trachoma, and inclusion conjunctivitis. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Active Ingredient The active ingredient contained in Divaine tablets is Minocycline Hydrochloride. Each film-coated Divaine tablet contains Minocycline Hydrochloride, BP equivalent to 50 mg or 100 mg of Minocycline. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Chemical Structure The structure of Minocycline Hydrochloride is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets are manufactured by Cipla Limited, India in the strength of 50 mg and 100 mg. (Website: www.cipla.com) URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Minocycline Hydrochloride Tablets – Brand Names Minocycline Hydrochloride tablets are available under various drug trade names that include Solodyn, Cynomycin from Wyeth, Divaine from Cipla , Minolox from Micro Gratia, Minoz from Ranbaxy and Nidcyclin from Nidus. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Uses of Divaine Tablets Divaine (Generic Minocycline Hydrochloride tablets) is used to treat pimples and red bumps (non-nodular inflammatory lesions) that occur with moderate to severe acne vulgaris in patients 12 years of age and older. Minocycline tablets are used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection and other infections in patients who cannot receive penicillins. Minocycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Dosage The dosage of Divaine tablets Divaine tablets (Generic Minocycline Hydrochloride tablets) for various indications is given below: Usual Adult Dose for Acne: Usual Adult Dose for Acne: The initial dose: 50 to 100 mg orally twice a day for 3 to 6 weeks or until improvement occurs and the maintenance dose: 50 to 100 mg orally once a day. Usual Adult Dose for Actinomycosis: Usual Adult Dose for Actinomycosis: The initial dosage is 100 mg orally every 12 hours. The duration of Initial parenteral therapy for 2 to 6 weeks, followed by oral therapy for a total duration of 6 to 12 months. Usual Adult Dose for Bacterial Infection: Usual Adult Dose for Bacterial Infection: 200 mg initially followed by 100 mg orally every 12 hours; alternatively, 100 to 200 mg initially followed by 50 mg orally 4 times a day has been used. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Dosage The dosage of Divaine tablets Divaine tablets (Generic Minocycline Hydrochloride tablets) for various indications is given below: Usual Adult Dose for Meningitis - Meningococcal: Usual Adult Dose for Meningitis - Meningococcal: Elimination of Neisseria meningitidis carrier state: 100 mg orally every 12 hours for 5 days. For this indication Rifampin, Ciprofloxacin, or Ceftriaxone are considered first-line agents. Usual Adult Dose for Skin or Soft Tissue Infection: Usual Adult Dose for Skin or Soft Tissue Infection: Mycobacterium marinum: marinum: 100 mg orally every 12 hours for at least 3 months. Vibrio vulnificus: Vibrio vulnificus: 100 mg orally every 12 hours plus Cefotaxime 2 g IV every 8 hours or Ceftazidime 1 to 2 g IV every 8 hours. Mycobacterium URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Dosage The dosage of Divaine tablets Divaine tablets (Generic Minocycline Hydrochloride tablets) for various indications is given below: Usual Adult Dose for Skin and Structure Infection: Usual Adult Dose for Skin and Structure Infection: Mycobacterium marinum: marinum: 100 mg orally every 12 hours for at least 3 months. Vibrio vulnificus: Vibrio vulnificus: 100 mg IV or orally every 12 hours plus Cefotaxime 2 g IV every 8 hours or Ceftazidime 1 to 2 g IV every 8 hours. Uncomplicated Gonococcal Infections Other Than Urethritis and Uncomplicated Gonococcal Infections Other Than Urethritis and Anorectal Infections: Anorectal Infections: In men, 200 mg initially, followed by 100 mg every 12 hours for a minimum of 4 days, with post-therapy cultures within 2 to 3 days. Adult females may require more prolonged therapy. Mycobacterium © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Dosage The dosage of Divaine tablets Divaine tablets (Generic Minocycline Hydrochloride tablets) for various indications is given below: Uncomplicated Gonococcal Urethritis in Men: Uncomplicated Gonococcal Urethritis in Men: 100 mg, every 12 hours, for 5 days is recommended. Uncomplicated Non-Gonococcal Urethral Infection in Adults Uncomplicated Non-Gonococcal Urethral Infection in Adults Caused by Chlamydia trachomatis or Ureaplasmaurealyticum: Caused by Chlamydia trachomatis or Ureaplasmaurealyticum: 100 mg orally, every 12 hours, for at least 7 days. Syphilis: Syphilis: The usual dosage of Divaine Tablets should be administered over a period of 10 to 15 days. Close follow-up, including laboratory tests, is recommended. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Dosage The dosage of Divaine tablets Divaine tablets (Generic Minocycline Hydrochloride tablets) for various indications is given below: Pneumonia Caused By Susceptible organisms: Pneumonia Caused By Susceptible organisms: The usual dosage of Divaine Tablets is 200 mg initially, followed by 100 mg every 12 hours. Alternatively, if more frequent doses are preferred, two or four 50 mg tablets may be given initially, followed by one 50 mg four times daily. Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Contraindications Divaine tablets are contraindicated in patients with a hypersensitivity to Minocycline Hydrochloride, any of the tetracyclines or any other component of this medication. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Storage Instructions Divaine (Generic Minocycline Hydrochloride tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Warnings While undergoing therapy with this medication, avoid sunlight, sunlamps, and tanning beds, since Divaine tablets can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get severe sunburn. Protect your skin while out in sunlight. You should not drive or operate dangerous machinery until you know how Divaine affects you. Divaine tablets can cause you to feel dizzy or lightheaded, or have a spinning feeling (vertigo). Advise patients that Minocycline may cause central nervous system side effects including light-headedness, dizziness, or vertigo. The use of Divaine (Minocycline tablets) during tooth development (last half of pregnancy, infancy, and childhood up to the age of 8 years) can cause permanent discoloration of the teeth (yellow-gray-brown). URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Warnings In case pseudomembranous colitis occurs, discontinue Divaine. If liver injury is suspected, discontinue Divaine. In case renal impairment exists, Minocycline doses may need to be adjusted to avoid excessive systemic accumulations of the drug and possible liver toxicity. Divaine (Minocycline Hydrochloride tablets) may cause pseudotumor cerebri (benign intracranial hypertension) in adults and adolescents. Discontinue in case symptoms occur. Minocycline has been associated with autoimmune syndromes; discontinue Divaine tablets immediately if symptoms occur. Divaine (Minocycline tablets) has been associated with anaphylaxis, serious skin reactions, erythema multiforme, and DRESS syndrome. Discontinue Minocycline tablets immediately in case symptoms are observed. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets and Alcohol Liver toxicity is believed to be a rare side effect of taking Minocycline (Divaine tablets). Alcohol has negative effects on the liver, so it is highly recommended that patients not consume alcohol while being prescribed Minocycline as this may exacerbate an already existing liver problem. Be aware that if you feel unwell with an infection or find Minocycline makes you feel dizzy, or gives you a headache or upset stomach, then this might be made worse by drinking alcohol. It's also possible that drinking excessive amounts of alcohol with Minocycline (Divaine tablets) could increase the risk of getting side effects on your liver. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Side Effects The most commonly observed Divaine (Minocycline Tablets) side effects with an incidence rate of 5% or more are headache, fatigue, dizziness, and pruritus. Side effects reported in clinical trials at a rate of 1% or more are for Headache, Fatigue, Dizziness, Pruritus, Malaise, Mood alteration, Somnolence, Urticaria, Tinnitus, Arthralgia, Vertigo, Dry mouth and Myalgia. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Side Effects Side effects that have been reported With Minocycline Hydrochloride use in a variety of indications during postmarketing include: Skin and hypersensitivity reactions: fixed drug eruptions, balanitis, erythema multiforme, Stevens-Johnson syndrome, anaphylactoid purpura, photosensitivity, pigmentation of skin and mucous membranes, hypersensitivity reactions, angioneurotic edema, anaphylaxis, DRESS syndrome. Autoimmune conditions: polyarthralgia, pericarditis, exacerbation of systemic lupus, pulmonary infiltrates with eosinophilia, transient lupus-like syndrome. Central nervous system: pseudotumor cerebri, bulging fontanels in infants, decreased hearing. Endocrine: brown-black microscopic thyroid discoloration, abnormal thyroid function. Oncology: thyroid cancer. Oral: glossitis, dysphagia, tooth discoloration. Gastrointestinal: enterocolitis, pancreatitis, hepatitis, liver failure. Renal: reversible acute renal failure. Hematology: hemolytic anemia, thrombocytopenia, eosinophilia. Preliminary studies suggest that use of minocycline may have deleterious effects on human spermatogenesis. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Overdose The adverse events more frequently observed in overdose are dizziness, nausea, and vomiting. No specific antidote for Minocycline tablets is known at present. In case of overdosage, discontinue Divaine tablets immediately, treat symptomatically and institute supportive measures. Minocycline is not removed in significant quantities by hemodialysis or peritoneal dialysis. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

21. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets During Pregnancy Minocycline Hydrochloride (Divaine Tablets) has been classified by the US FDA as Pregnancy Category D. Divaine should not be used during pregnancy. If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus and stop treatment immediately. There are no adequate and well-controlled studies on the use of Minocycline Hydrochloride (Divaine Tablets) in pregnant women. Minocycline, like other tetracycline-class drugs, crosses the placenta and may cause fetal harm when administered to a pregnant woman. Rare spontaneous reports of congenital anomalies including limb reduction have been reported with Minocycline use in pregnancy in post-marketing experience. Only limited information is available regarding these reports; therefore, no conclusion on causal association can be established. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

22. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets During Pregnancy Results of studies conducted in animal prove that tetracyclines cross the placenta, are found in foetal tissues and can have toxic effects on the developing foetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy, and childhood up to the age of 12 years) can cause permanent discolouration of the teeth (yellow to grey-brown). Tetracyclines including Divaine (Minocycline Hydrochloride tablets) are excreted in human milk. Due to the potential for serious adverse reactions in nursing infants from the tetracyclines, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the medicine to the mother. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

23. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets During Nursing Minocycline (Divaine tablets) can cause fetal harm and pass into breast milk. Minocycline may affect bone and tooth development in a fetus or nursing baby. Do not take this medication without telling your doctor if you are pregnant or breast-feeding a baby. Children should not take this medication. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

24. Divaine Tablets by Cipla (Generic Minocycline Hydrochloride Tablets) Divaine Tablets Divaine Tablets (Generic Minocycline Hydrochloride Tablets) manufactured by Cipla Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html https://www.clearskypharmacy.biz/generic-solodyn-divaine-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )