Nexpro Tablets (Generic Esomeprazole Magnesium Tablets)

1. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro (Generic Esomeprazole Magnesium Tablets) is used to treat gastro-esophageal reflux disease, erosive reflux esophagitis, prevention of relapse of esophagitis and helps in eradication of H. pylori associated peptic ulcer. It is also indicated for pathological hypersecretory conditions including Zollinger-Ellison syndrome ulcer, risk reduction of NSAID-associated gastric ulcer, and prolonged treatment after IV-induced prevention of rebleeding of peptic ulcer. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro tablets are manufactured by Torrent Pharmaceuticals Limited, India in the strengths of 20 mg and 40 mg. ( Website: https://www.torrentpharma.com/ https://www.torrentpharma.com/ ) URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Active Ingredient The active ingredient contained in Nexpro tablets is Esomeprazole Magnesium. Each enteric-coated Nexpro tablet contains Esomeprazole Magnesium Trihydrate IP equivalent to 20 mg or 40 mg of Esomeprazole. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Chemical Structure The structure of Esomeprazole Magnesium is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Esomeprazole Magnesium Tablets – Brand Names Esomeprazole Magnesium tablets are available under various drug trade names that include Nexium , Neksium, Nexpro, Sompraz, Raciper, Esomac, Esofag, Esorest, Lupisoz, Esotrax, Esoz, Espra, Estab and Izra. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Uses of Nexpro Tablets Nexpro (Generic Esomeprazole Magnesium Tablets) is used to treat conditions where there is too much acid in the stomach. It is used to treat duodenal and gastric ulcers, erosive esophagitis, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, a condition wherein the stomach produces too much acid. Esomeprazole is also used with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers that are caused by the H. pylori bacteria. This medicine is also used to prevent stomach ulcers and stomach irritation in patients taking NSAIDs (eg, aspirin, ibuprofen) for long periods of time. Esomeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid that is produced by the stomach. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Dosage The recommended dosage of Nexpro tablets Nexpro tablets (Generic Esomeprazole Magnesium tablets) is administered orally, at least one hour before meals. Nexpro tablets should be swallowed whole with liquid. The tablets should not be chewed or crushedThe dose for the various indications is: Treatment of Gastroesophageal Reflux Disease (GERD): Treatment of Gastroesophageal Reflux Disease (GERD): Recommended Adult Dose: 20 mg or 40 mg Once Daily for 4 to 8 Weeks Pediatric Dose for 1 to 11 years: 10 mg or 20 mg Once Daily, up to 8 Weeks Pediatric Dose for 12 to 17 years: 20 mg or 40 mg Once Daily, up to 8 Weeks Risk Reduction of NSAID-Associated Gastric Ulcer: Risk Reduction of NSAID-Associated Gastric Ulcer: Recommended Adult Dose: 20 mg or 40 mg Once Daily for up to 6 months. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Dosage The recommended dosage of Nexpro tablets Esomeprazole Magnesium tablets) for the various indications is: Pathological Hypersecretory Conditions Including Zollinger- Pathological Hypersecretory Conditions Including Zollinger- Ellison Syndrome: Ellison Syndrome: Recommended Adult Dose: 40 mg Twice Daily H. pylori Eradication to Reduce the Risk of Duodenal Ulcer H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence Triple Therapy: Recurrence Triple Therapy: The recommended adult dosage is Generic Esomeprazole (Nexpro) 40 mg once daily for 10 Days, Amoxicillin 1000 mg twice daily for 10 Days and Clarithromycin 500 mg twice daily for 10 Days Nexpro tablets (Generic URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Tablets Contraindications Nexpro tablets are contraindicated in patients with a hypersensitivity to Esomeprazole Magnesium, other proton pump inhibitors (PPIs) or any other component of this medication. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Storage Instructions Nexpro (Esomeprazole Magnesium tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Warnings Symptomatic response to therapy with Esomeprazole (Nexpro tablets) does not preclude the presence of gastric malignancy. Observational studies suggest that Proton Pump Inhibitor (PPI) therapy like Esomeprazole can be associated with an increased risk of Clostridium difficile associated diarrhea (CDAD), especially in hospitalized patients. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole, of which Esomeprazole is an enantiomer. Avoid concomitant use of Nexpro with Clopidogrel. Avoid concomitant use of Nexpro with St John's Wort or Rifampin due to the potential reduction in Esomeprazole levels. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Warnings Acute interstitial nephritis has been observed in patients taking PPIs including Esomeprazole Magnesium. Acute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reaction. Daily treatment with any acid-suppressing medications over a long period of time (e.g., longer than 3 years) may lead to malabsorption of cyanocobalamin (vitamin B-12) caused by hypo- or achlorhydria. Hypomagnesemia, symptomatic and asymptomatic, has been reported rarely in patients treated with PPIs for at least 3 months, in most cases after a year of therapy. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Warnings Several published observational studies suggest that PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine. The risk of fracture was increased in patients who were administered high-dose (defined as multiple daily doses), long-term PPI therapy (a year or longer). Serum chromogranin A (CgA) levels increase secondary to drug- induced decreases in gastric acidity. The increased CgA level can cause false-positive results in diagnostic investigations for neuroendocrine tumors. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Tablets Side Effects Most common Esomeprazole Magnesium (Nexpro Tablets) side effects in adults with an incidence rate of 1% or more include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth. Most common Esomeprazole Magnesium tablets side effects in pediatric (1 to 17 years) with an incidence rate of 2% or more are headache, diarrhea, abdominal pain, nausea, and somnolence. Most common Esomeprazole Magnesium tablets side effects in pediatric (1 month to less than 1 year) with an incidence rate of 1% or more include abdominal pain, regurgitation, tachypnea, and increased ALT. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Tablets Overdose The major signs of acute toxicity were reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions. In cases of doses ranged up to 2,400 mg (120 times the usual recommended clinical dose) the manifestations were variable, but included confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, dry mouth and other adverse reactions similar to those seen under normal clinical experience. No specific antidote for Esomeprazole tablets is currently known. Since Esomeprazole is extensively protein-bound, it is not expected to be removed by dialysis. In the event of overdosage, treatment should be symptomatic and supportive. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) Nexpro Tablets During Pregnancy Esomeprazole Magnesium (Nexpro tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well-controlled studies of Esomeprazole Magnesium (Nexpro tablets) use in pregnancy. With the racemic mixture, Omeprazole data on a larger number of exposed pregnancies from epidemiological studies indicate no malformative nor foetotoxic effect. Animal studies with Esomeprazole do not indicate direct or indirect harmful effects with respect to embryonal / foetal development. Animal studies with the racemic mixture do not indicate direct or indirect harmful effects with respect to pregnancy, parturition or postnatal development. Caution should be exercised when prescribing Esomeprazole to pregnant women. A moderate amount of data on pregnant women (between 300-1000 pregnancy outcomes) indicates no malformative or foeto/neonatal toxicity of Esomeprazole. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Nexpro Tablets (Generic Esomeprazole Magnesium Tablets) For more details on Nexpro Tablets click here Nexpro Tablets click here Nexpro (Generic Esomeprazole Magnesium Tablets) by Torrent Pharmaceuticals Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html https://www.clearskypharmacy.biz/generic-nexium-nexium-by-torrent.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )