Rpigat Tablets (Generic Rivaroxaban Tablets)

1. Rpigat Tablets (Generic Rivaroxaban Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets (Generic Rivaroxaban Tablets) is used to treat and prevent deep venous thrombosis (DVT), a condition in which harmful blood clots form in the blood vessels of the legs. Rivaroxaban tablets sometimes used to lower the risk of a blood clot coming back after the patient has received treatment for blood clots for at least 6 months. Rivaroxaban is also used in people with atrial fibrillation (a heart rhythm disorder) to lower the risk of stroke caused by a blood clot. Rpigat tablets also prevent the formation of blood clots in the veins or blood vessels of patients of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE). © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Rpigat Tablets (Generic Rivaroxaban Tablets) Active Ingredient The active ingredient contained in Rpigat tablets is Rivaroxaban. Each Rpigat tablet contains 10 mg, 15 mg or 20 mg of Rivaroxaban respectively. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Rpigat Tablets (Generic Rivaroxaban Tablets) Chemical Structure The structure of Rivaroxaban is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat tablets are manufactured by Natco Pharma Limited, India in the strengths of 10 mg, 15 mg and 20 mg. (Website: https://www.natcopharma.co.in/) URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Rpigat Tablets (Generic Rivaroxaban Tablets) Rivaroxaban Tablets – Brand Names Rivaroxaban tablets are available under various drug trade names such as Xarelto, Ixarola, Rivoxamac, Rivaflo, Cameriv, Rivaxa, Alriza, Lotoron, Xavian and Xarocad. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Rpigat Tablets (Generic Rivaroxaban Tablets) Uses of Rpigat Tablets Rpigat (Generic Rivaroxaban Tablets) is used for the treatment of the following indications: Prevention of venous thromboembolism (VTE) in adult patients undergoing elective hip or knee replacement surgery. Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation with one or more risk factors, such as congestive heart failure, hypertension, age 75 years and above, diabetes mellitus, prior stroke or transient ischaemic attack. Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and for the prevention of recurrent DVT and pulmonary embolism. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Rpigat Tablets (Generic Rivaroxaban Tablets) Uses of Rpigat Tablets Rpigat (Generic Rivaroxaban Tablets), in combination with aspirin, is indicated for the prevention of major cardiovascular events (composite of stroke, myocardial infarction and cardiovascular death) in patients with coronary artery disease (CAD) and/or peripheral artery disease (PAD). URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets Dosage The dosage of Rpigat tablets (Generic Rivaroxaban Tablets) is given below: Nonvalvular Atrial Fibrillation: For patients with Creatinine clearance (CrCl) greater than 50 mL/min: 20 mg orally, once daily with the evening meal. For patients with CrCl 15 to 50 mL/min: 15 mg orally, once daily with the evening meal. Avoid use in patients with CrCl less than 15 mL/min. Prophylaxis of Deep Vein Thrombosis (DVT): 10 mg orally, once daily with or without food. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets Dosage The dosage of Rpigat tablets (Generic Rivaroxaban Tablets) is given below: Hepatic impairment (for nonvalvular AF and prophylaxis of DVT indications): Avoid use in patients with moderate (Child-Pugh B) and severe (Child-Pugh C) hepatic impairment or with any degree of hepatic disease associated with coagulopathy. A doctor should be consulted immediately if you happen to take more than the prescribed dose of Rpigat tablets since excessive intake of these tablets could put you at an increased risk of bleeding. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Rpigat Tablets (Generic Rivaroxaban Tablets) Contraindications Rpigat tablets are contraindicated in patients with a hypersensitivity to Rivaroxaban or any inactive ingredient present in Rpigat tablets. Rpigat tablets contraindicated in patients with health conditions that could result in active bleeding such as recent gastrointestinal ulceration, presence of malignant neoplasms at high risk of bleeding, recent brain or spinal injury, recent brain, spinal or ophthalmic surgery, recent intracranial haemorrhage, known or suspected oesophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular abnormalities. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Rpigat Tablets (Generic Rivaroxaban Tablets) Contraindications Other Rpigat tablets contraindications include Hepatic disease associated with coagulopathy and clinically relevant bleeding risk including cirrhotic patients with Child Pugh B and C as well as pregnancy and breast- feeding. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Rpigat Tablets (Generic Rivaroxaban Tablets) Storage Instructions Rpigat tablets (Generic Rivaroxaban tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Rpigat Tablets (Generic Rivaroxaban Tablets) Warnings Risk of bleeding: Rpigat tablets can cause serious and fatal bleeding. An agent to reverse the activity of rivaroxaban is available. Pregnancy-related hemorrhage: Use Rpigat tablets with caution in pregnant women due to the potential for obstetric hemorrhage and/or emergent delivery. Prosthetic heart valves: Rpigat tablets use not recommended. Increased Risk of Thrombosis in Patients with Triple Positive Antiphospholipid Syndrome: Rpigat tablets use not recommended. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets Side Effects The most common Rivaroxaban (Rpigat tablets) side effect with an incidence rate of 5% or more in adult patients was bleeding. The most common Rivaroxaban (Rpigat tablets) side effects with an incidence rate of 10% or greater in pediatric patients were bleeding, cough, vomiting, and gastroenteritis. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Rpigat Tablets (Generic Rivaroxaban Tablets) Overdose Overdose of Rivaroxaban (Rpigat tablets) may lead to hemorrhage. Discontinue Rpigat tablets and initiate appropriate therapy if bleeding complications associated with overdosage occur. Rivaroxaban systemic exposure is not further increased at single doses more than 50 mg due to limited absorption. The use of activated charcoal to reduce absorption in case of Rivaroxaban overdose may be considered. Due to the high plasma protein binding, Rivaroxaban is not dialyzable. Partial reversal of laboratory anticoagulation parameters may be achieved with use of plasma products. An agent to reverse the anti- factor Xa activity of Rivaroxaban is available. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets During Pregnancy Rivaroxaban (Rpigat tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate or well-controlled studies of Rivaroxaban tablets in pregnant women. Safety and efficacy of Rivaroxaban tablets have not been established in pregnant women. Studies in animals have shown reproductive toxicity. Due to the potential reproductive toxicity, the intrinsic risk of bleeding and the evidence that Rivaroxaban passes the placenta, Rivaroxaban (Rpigat tablets) is contraindicated during pregnancy. Women of child-bearing potential should avoid becoming pregnant during treatment with Rivaroxaban. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Rpigat Tablets (Generic Rivaroxaban Tablets) For more details on Rpigat Tablets click here Rpigat tablets (Rivaroxaban tablets) by NATCO Pharma Limited, India. URL: https://www.clearskypharmacy.biz/generic-rivaroxaban-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )