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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic nervous system. SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of the sympathetic nervous system. Indirect Acting. Direct Acting. Drugs that facilitate NE release.
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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic nervous system
SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of the sympathetic nervous system. Indirect Acting Direct Acting Drugs that facilitate NE release -adrenergic agonists Drugs that block NE uptake -adrenergic agonists
Drugs that inhibit NE synthesis Ganglionic blocking drugs Centrally acting sympatholytics SYMPATHOLYTICS: Drugs that reduce or inhibit some or all of the actions of the sympathetic nervous system. NE depleting drugs -adrenergic antagonists -adrenergic antagonists Adrenergic neuronal blocking drugs
PARASYMPATHOMIMETICS (CHOLINOMIMETICS): Drugs that facilitate or mimic some or all of the actions of the parasympathetic nervous system. Muscarinic receptor agonists Anticholinesterases
PARASYMPATHOLYTICS (ANTICHOLINERGICS): Drugs that reduce or inhibit some or all of the actions of the parasympathetic nervous system. Muscarinic receptor antagonists Ganglionic blocking drugs
Predicting Responses of Drugs that Interact with the Autonomic Nervous System
Baroreceptor Reflex Histamine Phenylephrine BP (mmHg) SNA (Units) PSNA (Units) HR (bpm) Time (minutes)
Predicting Responses 1 & 2 1, 2, 1 & 2 1, 1 & 2
Heart Rate Blood Pressure ACH (2 mg) ACH (50 mg) (Atropine: Muscarinic Receptor Antagonist) ACH (50 mg) ACH (5 mg) (Hexamethonium: Neuronal Nicotinic Receptor Antagonist) ACH (5 mg)