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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic

INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic nervous system. SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of the sympathetic nervous system. Indirect Acting. Direct Acting. Drugs that facilitate NE release.

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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic

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  1. INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part VI Interaction of drugs with the autonomic nervous system

  2. SYMPATHOMIMETICS: Drugs that facilitate or mimic some or all of the actions of the sympathetic nervous system. Indirect Acting Direct Acting Drugs that facilitate NE release -adrenergic agonists Drugs that block NE uptake -adrenergic agonists

  3. Drugs that inhibit NE synthesis Ganglionic blocking drugs Centrally acting sympatholytics SYMPATHOLYTICS: Drugs that reduce or inhibit some or all of the actions of the sympathetic nervous system. NE depleting drugs -adrenergic antagonists -adrenergic antagonists Adrenergic neuronal blocking drugs

  4. PARASYMPATHOMIMETICS (CHOLINOMIMETICS): Drugs that facilitate or mimic some or all of the actions of the parasympathetic nervous system. Muscarinic receptor agonists Anticholinesterases

  5. PARASYMPATHOLYTICS (ANTICHOLINERGICS): Drugs that reduce or inhibit some or all of the actions of the parasympathetic nervous system. Muscarinic receptor antagonists Ganglionic blocking drugs

  6. Predicting Responses of Drugs that Interact with the Autonomic Nervous System

  7. Baroreceptor Reflex

  8. Baroreceptor Reflex Histamine Phenylephrine BP (mmHg) SNA (Units) PSNA (Units) HR (bpm) Time (minutes)

  9. Predicting Responses 1 & 2 1, 2, 1 & 2 1, 1 & 2

  10. Heart Rate Blood Pressure ACH (2 mg) ACH (50 mg) (Atropine: Muscarinic Receptor Antagonist) ACH (50 mg) ACH (5 mg) (Hexamethonium: Neuronal Nicotinic Receptor Antagonist) ACH (5 mg)

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