Department of Pharmacology Overview 2007-2008

1. Department of PharmacologyOverview 2007-2008 Heidi E. Hamm, Ph.D. Earl W. Sutherland, Jr. Professor of Pharmacology Chair, Department of Pharmacology

2. Pharmacology Faculty PHARMACOLOGY Receptors & Signal Transduction Hamm Sanders-Bush Conn Gurevich Brown Barnett Wadzinski Neuroscience Blakely Emeson Levitt Gurevich Shieh Stanwood Konradi Current search Synaptic electro-physiologist Clinical Pharmacology Roberts Brash Roden Oates Brown Schneider Knollman Mundy Davies Drug Discovery Conn Forster Weaver Lindsley Future search DMPK with Clin Pharm Structural Biology Gurevich Hamm Iverson Spiller Systems Biology Chung Brown Hamm Forster

3. 2007 Sean Davies 2008 Christine Konradi Current Recruitment:neuroscience – synaptic electrophysiologist Targets of opportunity: Jon Schoenecker Ana Carneiro Carrie Jones Future Recruitments: signal transduction cancer pharmacology drug disposition systems biology Pharmacology Recruitment

4. Sean Daviesstudies the lipid products of oxidative stress, the isoketals He is a joint recruit with Clinical Pharmacology He recently received the 2007 NIH Director’s New Innovator Award to develop better long-term treatment strategies for chronic diseases using probiotic bacteria engineered to produce therapeutic compounds. Our New Faculty Recruits

5. Christine Konradi is a new Faculty Member in Pharmacology – she joined us from the Psychiatry Department She trained in the Univ. of Vienna, the Univ. of Wurzburg, Univ. of Medicine and Dentistry of New Jersey, and the Mass General Hospital, Harvard Med. School. Our New Faculty Recruits • Christine works on the role of psychostimulants in • gene regulation in psychiatric disorders • She has two R01 grants

6. Reputation Citations NIH funding National Responsibilities & Honors Leadership roles How are we doing?

7. Pharmacology Funding1998 - 2008 We’ve had an incredible year!

8. Pharmacology Funding withDrug Discovery Highlighted

9. Ratio of $ Awarded to Development $ Spent(Average ROI is $8 awarded to every $1 spent in development)

10. New Grants

11. 2007-8: Our Faculty Have Obtained National Grants and Awards • Craig Lindsley is PI on a MLPCN Chemistry Center Grant for $18M! This is one of only two in the country. • He also has 2 new R01s

12. Jeff Conn has received large grants from the Michael J. Fox Foundation for Parkinson’s Research and from Seaside Therapeutics for studies of Fragile-X Syndrome He also has 5 R01 grants National Grants and Awards

13. Randy Blakely received a NIMH Conte Center grant on Genes Controlling Assembly and Function of Serotonin Systems. Participants include Elaine Sanders-Bush, Pat Levitt, Ron Emeson, Doug McMahon and Evan Deneris Randy also has a R37 MERIT award, a R01 grant, and a PPG on Presynaptic Choline Transporters, as well as a training grant National Grants and Awards

14. Heidi Hamm is part of a Specialized Center of Clinically Oriented Research (SCCOR) on Thrombosis from NHLBI to study Thrombin Signaling in Platelets She also has 3 R01s National Grants and Awards

15. Alex Brown received a new “Systems Biology of Infectious Disease” Grant to study influenza virus interaction with its host, with Alan Aderem of the Institute for Systems Biology He also received the renewal of the Lipid MAPS Glue Grant National Grants and Awards

16. Vsevolod Gurevich received a new grant from NIGMS entitled “Conformational regulation of arrestin-mediated signaling” He also has two other R01 grants National Grants and Awards

17. Joey Barnett is a part of the Systems-based Consortium for Organ Design and Engineering (SysCODE) He also has an R01 and an AHA grant, as well as two training grants National Grants and Awards

18. Brian Wadzinski – renewed his NIGMS R01 grant on protein kinase/PP2A complexes He also has another R01 grant Eugenia Gurevich received a Michael J. Fox Foundation Grant National Grants and Awards

19. Tony Forster received a Pilot Grant from the Vanderbilt Diabetes Center He also has an R01 and an ACS Research Scholargrant National Grants and Awards

20. National Grants and Awards • Tina Iverson received a NARSAD award on “Allosteric Nucleotide Exchange in G protein a subunits” • She also has an R01 grant and a VICB pilot grant

21. Randy Blakely–2008 ASPET Julius Axelrod Award; 2008 ASPET-Astellas Award in Translational Pharmacology National Awards • Jeff Conn -- PhARMA Foundation Award for Excellence in Pharmacology and Toxicology

22. Dan Roden -- 2008 Rawls Palmer Award for Progress in Medicine, American Society for Clinical Pharmacology and Therapeutics National Awards • Joey Barnett -- AHA Southeast Affiliate Science Integration Award

23. MERIT awards: Randy Blakely, Elaine Sanders-Bush, Jack Roberts Editor of Molecular Pharmacology, Jeff Conn Associate Editors of Molecular Pharmacology, Alex Brown, Randy Blakely, Al George NIH Peer Review Advisory Committee, Heidi Hamm HHMI Review Board,Heidi Hamm President, American Society for Biochemistry & Molecular Biology Heidi Hamm Our Faculty are Distinguished Leaders Nationally

24. Pat Levitt – NINDS Strategic Plan Committee; Chair, High Risk/High Impact Program Committee, Autism Speaks Foundation; NIMH Blue Ribbon Panel on Intramural Research Programs Joey Barnett -- co-chair April 2008: Pharmacology Education for the Next 100 Years, San Diego, CA; Chair, American Heart Association Greater Southeast Affiliate Research Committee Alex Brown, Organizer/Chair for FASEB meeting on Phospholipases, July 2008 Our Faculty are Distinguished Leaders Nationally, cont’d

25. Heidi Hamm -- Member, FASEB Science Policy Committee Peer Review Subcommittee; Board Advisor, FASEB Excellence in Science Awards Committee, 2007-08; Member, AAMC Panel on Safe and Effective Prescribing Practices Jeff Conn: Chair,Division of Neuropharmacology, ASPET; Scientific advisory board member, Stanley Center for Psychiatric Research, Broad Institute; Technical Evaluation Panel, NIMH Program Review Our Faculty are Distinguished Leaders Nationally, cont’d

26. Jeff Conn – named Lee E. Limbird Professor of Pharmacology Our Faculty Receive Kudos at home • Nancy Brown - 2008 Elaine Sanders-Bush Faculty Award for Mentoring

27. Joey Barnett was elected to the Vanderbilt Academy for Excellence in Teaching Our Faculty Receive Kudos at Home

28. Randy Blakely - Director, Center for Molecular Neuroscience, Director, Vanderbilt/NIMH Silvio O. Conte Center for Neuroscience Research Pat Levitt – Director, Kennedy Center Jeff Conn - Director, Program in Drug Discovery, Director, Program in Translational Neuropharmacology Dan Roden - Director, Oates Institute of Therapeutic Discovery, Asst. Vice-Chancellor for Personalized Medicine, Principal Investigator, Vanderbilt DNA Database Jack Roberts – Faculty Senate Vice Chair-Elect Our Faculty are Campus Leaders

29. Nancy Brown - Associate Dean for Clinical and Translational Scientist Development, Director, Vanderbilt (K12) Clinical Research Scholars Program Heidi Hamm - Internal Advisory Board, Vanderbilt University Vanderbilt Institute for Clinical and Translational Research, CTSA; Medical Scientist Training Program Faculty Advisory Committee Ron Emeson – Chair, Institutional Animal Care and Use Committee; University Faculty Senate Academic Programs and Services Committee Tina Iverson serves on the Center for Structural Biology Executive Committee, as well as the Chemical Biology Interface Training Grant Executive Committee Gregg Stanwood is Associate Director, Vanderbilt Mouse Neurobehavioral Core Our Faculty are Campus Leaders, Continued

30. Full Members Joey Barnett Randy Blakely Alex Brown Chang Chung Seva Gurevich Ron Emeson Craig Lindsley Christine Konradi Study Section Members • Ad-hoc Members • Tony Forster

31. Vanderbilt ranks # 5 in The Most-Cited Institutions in Pharmacology & Toxicology, 1996-2006 We are Highly Cited

32. The index uses only objective criteria to calculate the scholarly productivity of individual faculty. It rates faculty members' scholarly output at nearly 7,300 doctoral programs around the country. The index was devised by Lawrence B. Martin, graduate dean at the State University of New York at Stony Brook. It uses faculty publications, citations, awards and grants which it obtains from the web. A New Faculty Scholarly Productivity Index

33. Use of the objective criteria of faculty publications, citations, awards and grants makes clear how strong our faculty are. Main difference this year is # of faculty they found; 100 this year, 45 last year In 2007, Vanderbilt Pharmacology Ranks # 6 in the Country

34. Pat Levitt - Director, Vanderbilt Kennedy Center; will be moving in June 2009 to become the Director of the Zilkha Neurogenetic Institute, Chair of Cell and Neurobiology Goodbye, we’ll miss you…

35. Lou DeFelice has gone to Virginia Commonwealth University to be Director of Graduate Studies in Physiology and Biophysics and Assistant Dean for Graduate Education Goodbye, we’ll miss you…

36. Managing fast growth – puts stress on faculty, administration, space Funding in a flat NIH environment – faculty need to be ever more adventuresome about finding funding; bridge funding is SO appreciated! Economic crisis affects us all, individually, the department, the institution. Our Challenges

37. Pharmacology Administrative Headcount