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Aggressive Short-Term Diet and Exercise Reduce CV Risk Without Major Weight Loss

Aggressive Short-Term Diet and Exercise Reduce CV Risk Without Major Weight Loss. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9 and monocyte chemotactic activity in men with metabolic syndrome factors

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Aggressive Short-Term Diet and Exercise Reduce CV Risk Without Major Weight Loss

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  1. Aggressive Short-Term Diet and Exercise Reduce CV Risk Without Major Weight Loss Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9 and monocyte chemotactic activity in men with metabolic syndrome factors Roberts CK et al. J Appl Physiol. 2006;100:1657-65.

  2. Rationale • Worldwide, CVD is the chief cause of morbidity and mortality, responsible for ~1 of 2.7 US deaths • Serum lipid levels are excellent predictors of CVD • High levels of oxidative stress, inflammation, endothelial dysfunction, platelet activation, and plaque instability also indicate CVD risk • Lifestyle modifications, including diet and exercise, can reduce traditional CV risk factors • Whether aggressive, short-term lifestyle modifications ameliorate underlying atherosclerotic disease remains to be proven AHA. Heart disease and stroke statistics–2006 update. Circulation. 2006;113:e85-151. Roberts CK et al. J Appl Physiol. 2006;100:1657-65.

  3. Aggressive, short-term lifestyle intervention effects on CV risk factors Roberts CK et al. J Appl Physiol. 2006;100:1657-65.

  4. Less diabetes and obesity without major weight loss * P < 0.01 • Lifestyle intervention showed: • CV risk reductions in the absence of major weight loss • Significant decrease in HOMAIR (P < 0.01) * * kg/m2 Metabolicsyndrome† Diabetes Obesity *P not available†Modified WHO criteria Roberts CK et al. J Appl Physiol. 2006;100:1657-65. Lakka HM et al. JAMA. 2002;288:2709-16.

  5. Favorable metabolic changes μU/mL *P < 0.01 †P < 0.05 Roberts CK. et al. J Appl Physiol. 2006;100:1657-65.

  6. Favorable changes in oxidative stress and inflammation pg/mL mg/L *P < 0.05; †P < 0.01 MPO = myeloperoxidase 8-iso-PGF2α = 8-isoprostaglandin F2αCRP = C-reactive protein sICAM-1 = soluble intracellular adhesion molecule 1 Roberts CK. et al. J Appl Physiol. 2006;100:1657-65.

  7. Summary of results Aggressive, short-term lifestyle intervention showed reductions in the absence of major weight loss: • Traditional risk factors • Obesity ↓18% • Diabetes ↓45%; glucose ↓12%, insulin ↓30% • Serum lipids: total-C ↓21%, LDL-C ↓25%, HDL-C ↓10%, TG↓28% • Metabolic syndrome ↓60% • Biomarkers • Oxidative stress: MPO ↓20%, 8-iso-PGF2α ↓35% • Inflammation: CRP ↓39%, sICAM-1 ↓20%, sP-selectin ↓8% Study limitations • Close supervision may be necessary to achieve these results • Not a controlled study Intensive lifestyle modification reduces CV risk factors in highly motivated overweight/obese men Roberts CK. et al. J Appl Physiol. 2006;100:1657-65.

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