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LC-MS/MS positive ion MRM detection MH + m/z 462 to 286

Stereoselective Flunoxaprofen- S -Acyl-Glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes Mark P. Grillo, Jill C. M. Wait, Michelle Tadano Lohr, Smriti Khera, and Leslie Z. Benet Drug Metabolism & Disposition. LC-MS/MS positive ion MRM detection

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LC-MS/MS positive ion MRM detection MH + m/z 462 to 286

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  1. Stereoselective Flunoxaprofen-S-Acyl-Glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes Mark P. Grillo, Jill C. M. Wait, Michelle Tadano Lohr, Smriti Khera, and Leslie Z. Benet Drug Metabolism & Disposition LC-MS/MS positive ion MRM detection MH+m/z 462 to 286 FLX-1-O-G formed in incubations of (S)-(+)-FLX (10 µM) with rat hepatocytes (10-min). * Supporting Data, FIG. 2. Representative reverse-phase gradient LC-MS/MS chromatograms of FLX‑1-O-G from analysis of extracts from rat hepatocytes incubated for 10‑ to 60-min with 10 µM (S)‑(+)‑FLX. The acyl glucuronides were detected by LC‑MS/MS analysis in the positive ion scan mode using the MRM transition MH+m/z 462 to m/z 286. The relative abundances for each trace on the y-axes are equal (and equal to the y-axes of the Supporting Information Fig. 1). (*Denotes acyl migration isomer as indicated in the 60-min trace.)

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