1 / 1

Efficient Synthesis of Heterocycles with the Aid of Electrophilic

Efficient Synthesis of Heterocycles with the Aid of Electrophilic Cyclizations and Fluorous Chemistry. Roman Dembinski, Department of Chemistry, Oakland University.

Download Presentation

Efficient Synthesis of Heterocycles with the Aid of Electrophilic

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Efficient Synthesis of Heterocycles with the Aid of Electrophilic Cyclizations and Fluorous Chemistry Roman Dembinski, Department of Chemistry, Oakland University Ligand-free 5-endo-dig cyclization of 1,4- and 1,2,4-substituted but-3-yn-1-yl (homopropargyl) azides in the presence of zinc chloride (usually 20 mol %) in dichloroethane at elevated temperature provides 2,5-di- and 2,3,5-trisubstituted pyrroles in high to moderate yields (91-41%). Both conventional and microwave protocols furnished comparable results. A structure of 2-(4-fluorophenyl)-5-(4-methylphenyl)-1H-pyrrole was confirmed by X-ray crystallography.

More Related