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May 27, 2008 Mony de Leon Professor of Psychiatry NYU School of Medicine 212 263 7563 mony.deleonmed.nyu

BIOMARKER ISSUES. PATHOLOGIC SPECIFICITYEARLY DIAGNOSTIC SENSITIVITYCORRELATION WITH PROGRESSION. Bobinski, de Leon, Wegiel and Wisniewski 2000. Biomarker: Hippocampal atrophy. Synaptic Pathology Alzheimer Normal. Confocal images with anti-synaptophysin. Robert Terry UCSD. Biomarker: Glucose metab..

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May 27, 2008 Mony de Leon Professor of Psychiatry NYU School of Medicine 212 263 7563 mony.deleonmed.nyu

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    1. May 27, 2008 Mony de Leon Professor of Psychiatry NYU School of Medicine 212 263 7563 mony.deleon@med.nyu.edu

    2. BIOMARKER ISSUES PATHOLOGIC SPECIFICITY EARLY DIAGNOSTIC SENSITIVITY CORRELATION WITH PROGRESSION

    4. Synaptic Pathology Alzheimer Normal Confocal cortical images with anti synaptophysin of AD (left) and a normal control brain (right). Each green granule is a presynaptic body. Confocal cortical images with anti synaptophysin of AD (left) and a normal control brain (right). Each green granule is a presynaptic body.

    7. Tangles as drawn by Bonfiglio in 1908 with silver stain. The senile tangle as drawn by Bonfiglio in 1908. The senile tangle as drawn by Bonfiglio in 1908.

    19. CSF Biomarkers and Incident CDR>0

    21. Accuracy for FDG and PIB

    24. Conclusions Early markers are progression sensitive but not specific FDG-PET, MRI volume, and isoprostane. Is the P-tau /A? ratio an exception? Pathology biomarkers are not progression sensitive P-tau231, T-tau, A?42, A?40, PIB-PET?

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