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Cells Interact with their Environment: The Extracellular Matrix

Cells Interact with their Environment: The Extracellular Matrix. What is the extracellular matrix?. Extra (E) cellular (C) matrix (M) Outside/outer of the cell surroundings within which something is contained The part of animal tissue (outside of the cells) that provides

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Cells Interact with their Environment: The Extracellular Matrix

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  1. Cells Interact with their Environment:The Extracellular Matrix

  2. What is the extracellular matrix? • Extra (E) cellular (C) matrix (M) Outside/outer of the cell surroundings within which something is contained • The part of animal tissue (outside of the cells) that provides __________________________ to the cells contained within. What is the ECM composed of? • _____________________: large polysaccharides with net negative charge, attracting __________ ions, such as ______, which then cause ___________ accumulation, _______________________ • _________: collagen & elastin, which provide ______________ • Cell adhesion proteins: fibronectin, which provides anchor points for cells to ____________ to.

  3. Cell Interaction with the ECM (Migration) • Steps: • 1. Protrusion • 2. Adhesion • 3. Contraction • 4. Release

  4. How might a scientist study cell-ECMinteractions? • What characteristics might a synthetic ECM need • What materials might havethese desired qualities?

  5. What is a polymer? • Poly - mer - Definition: polymers are long-chain molecules consisting of repeating units (called: ______________) which are typically connected by ___________ chemical bonds. • Synthetic Example Polyethylene (PE): CH2=CH2 CH2(CH2CH2)n • Natural Example polysaccharide: Chitosan, randomly distributed D-glucosamine and N-acetyl-D-glucosamine units

  6. Characterization of Polymers • Skeletal structure: • Primary structure: • Homopolymer (1 monomer species) • –A-A-A-A-A-A- • Copolymer (2 or more monomer species) • Random –A-B-A-A-B-A-B • Block –A-A-A-B-B-B- • Alternating –A-B-A-B-A-B Free Crosslinked Linear Branched

  7. Polymer Usage as a Biomaterial • What is a biomaterial? • Examples:

  8. Carbon Ring Numbering

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